Active substanceMagnesium sulfateMagnesium sulfate
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  • Dosage form: & nbsp

    Powder for solution for oral administration

    Composition:

    Magnesium sulfate 10.0 g or 20.0 g.

    Description:Colorless prismatic crystals that weathered in the air.
    Pharmacotherapeutic group:Laxative
    ATX: & nbsp

    A.12.C.C   Preparations of magnesium

    Pharmacodynamics:

    When ingestion has a laxative effect due to the accumulation of water in the intestine, liquefaction of intestinal contents and increased peristalsis. Has a reflex choleretic effect.

    Pharmacokinetics:

    Poorly absorbed in the gastrointestinal tract (no more than 20 %). Passes through the blood-brain barrier and placenta, creates in breast milk concentrations of 2 times the concentration in the plasma. Excretion by the kidneys, the rate of renal excretion is proportional to the concentration in the plasma and the level of glomerular filtration.

    Indications:

    Applied sporadically as a laxative, to prepare for studies of the large intestine and poisoning with soluble salts of barium.

    Contraindications:

    Hypersensitivity to magnesium sulfate, appendicitis, rectal bleeding (including suspected), intestinal obstruction, dehydration, acute inflammatory diseases of the gastrointestinal tract, pregnancy, lactation period, hypermagnesia.

    Carefully:Blockade of the heart, myocardial damage, chronic renal failure.
    Pregnancy and lactation:Contraindicated in pregnancy and lactation.
    Dosing and Administration:

    Inside. Adults: 20 g once a day on an empty stomach, previously dissolving the contents of 2 packets or one jar in 100 ml of warm water.

    Have children, the drug can be used only as directed by a doctor. Daily doses are determined from the calculation of 1 g for 1 year of life.

    It is possible to use the drug in the form of enemas (50-100 ml of 20-30% solution).

    When poisoning with soluble barium salts, wash the stomach with 1% magnesium sulfate solution or give the solution inside (20 g in 200 ml of water) to form insoluble barium sulfate.

    Side effects:

    Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, electrolyte imbalance (fatigue, asthenia, confused consciousness, arrhythmia, convulsions), flatulence, thirst, signs of hypermagnesia in the presence of kidney failure (dizziness).

    early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden "tide" of blood to the skin of the face, headache, lowering of blood pressure, nausea, shortness of breath, blurred speech, vomiting, weakness.

    Symptoms of hypermagnia (in order of increasing concentrations Mg2+ in the serum): a decrease in deep tendon reflexes (2-3.5 mmol / l), an interval P-Q and expansion of the complex QRS on the ECG (2.5-5 mmol / L), loss of deep tendon reflexes (4-5 mmol / L), respiratory center depression (5-6.5 mmol / L), cardiac conduction (7.5 mmol / L), cardiac arrest (12.5 mmol / l). In addition, hyperhidrosis, anxiety, deep sedation, polyuria, atony of the uterus.

    Overdose:

    Symptoms: severe diarrhea.

    Treatment: - symptomatic.

    Interaction:

    Reduces the effect of oral anticoagulants (including coumarin derivatives or derivatives of indanedione), cardiac glycosides, phenothiazines (especially chlorpromazine).Reduces the absorption of ciprofloxacin, etidronic acid, antibiotics of the tetracycline group (forms unabsorbed complexes with oral tetracyclines), weakens the effects of streptomycin and tobramycin (laxative Mg2 + containing medicines should be taken 1-2 hours after the application of the above drugs).

    Pharmaceutically incompatible with Ca2 + preparations, ethanol (in high concentrations), carbonates, hydrocarbonates and phosphates of alkali metals, arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin In sulfate, procaine hydrochloride, salicylates and tartrates .

    Special instructions:

    A drug should be taken occasionally, systematic use is not recommended.

    Form release / dosage:

    Powder for solution for oral administration.

    Packaging:In heat-sealing bags of 10 g. In banks of dark glass for 20 g. Each jar with instructions for use or 3 packages with instructions for use are placed in a pack of cardboard.
    Storage conditions:

    Store in a dry and inaccessible place for children at a temperature not exceeding + 25 ° C.

    Shelf life:

    5 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-001325/10
    Date of registration:24.02.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:YAROSLAVSK PHARMACEUTICAL FACTORY, CJSC YAROSLAVSK PHARMACEUTICAL FACTORY, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.03.2018
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