Mexidol® is an inhibitor of free-radical processes, a membrane protector possessing antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic action. The drug increases the resistance of the body to the effects of various damaging factors (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication with alcohol and antipsychotic drugs (neuroleptics)).
The mechanism of action of Mexidol® is due to its antioxidant, antihypoxic and membrane-protective action.It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Mexidol® modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase),
Receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, contributes to the preservation of the structurally functional organization of biomembranes, the transport of neurotransmitters and the improvement of synaptic transmission. Meksidol® increases the content in the brain of dopamine. It causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition at oxidative processes in the Krebs cycle. Under conditions of hypoxia with an increase in the content of ATP and creatine phosphate, activation of energy-synthesizing functions of mitochondria, stabilization of cell membranes.
The drug improves metabolism, and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells; (erythrocytes and platelets) during hemolysis.Has a hypolipidemic effect, reduces the content of total cholesterol and low-density lipoproteins.
Anti-stress effect is the normalization of post-stress behavior, somatovegetativnyh violations, restoration of the sleep-wake cycles, broken processes of learning and memory, and reducing degenerative morphological changes in different brain structures.
Mexidol® has a pronounced antitoxic effect on withdrawal symptoms. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral, autonomic functions, as well as able to shoot cognitive impairment caused by prolonged use of ethanol and its abolition. Under, the influence Meksidola® amplified tranquilizing action, neuroleptics, antidepressants, hypnotics and anticonvulsants, to reduce their dose and reduce side effects. Mexidol® improves the functional state of the ischemic myocardium. In the context of coronary insufficiency increases collateral blood flow to ischemic myocardium, it helps to preserve the integrity of cardiomyocytes and maintaining their functional activity.Effectively restores myocardial contractility with reversible cardiac dysfunction.