Active substanceEthyl methylhydroxypyridine succinateEthyl methylhydroxypyridine succinate
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  • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    Active substances: 50 mg of ethyl methylhydroxypyridine succinate in 1 ml of solution;

    Excipients: water for injections.

    Description:Practically colorless or slightly colored transparent liquid.
    Pharmacotherapeutic group:Antioxidant
    ATX: & nbsp

    N.07.X.X   Other drugs for the treatment of diseases of the nervous system

    Pharmacodynamics:Mexidant® belongs to the class of 3-hydroxypyridines. It has antioxidant, antihypoxic, membrane stabilizing, nootropic, anxiolytic action. It inhibits the processes of lipid peroxidation, increases the activity of the antioxidant system of enzymes (superoxide dismutase, catalase, peroxidase), restores the damaged structure and functions of membranes, modulates calcium and potassium ion channels, transport neurotransmitters, and improves synaptic transmission. The drug increases the resistance of the body to the effects of various damaging factors (shock, hypoxia, ischemia, trauma, cerebral circulation disorders, activating the energy-synthesizing functions of mitochondria and improving energy metabolism in the cell.
    Pharmacokinetics:

    With a single and course application of Mexidant® the maximum concentration in the blood plasma (CmOh) is achieved after 0.58 hours. When administered at a dose of 400-500 mg Cmax in blood plasma - 3.5-4 μg / ml. Quickly distributed in organs and tissues. The average retention time is 0.7-1.3 hours. At the same time, Mexident® is rapidly excreted from the blood plasma and after 4 hours is practically not detected in it.

    Pharmacokinetic profiles do not differ significantly in single or continuous administration. It is excreted in the urine, both in unchanged form, and in the form of glucuronconjugates.

    Five metabolites were identified: the liver formed the first metabolite - phosphate 3-hydroxypyridine - which in the blood under the influence of alkaline phosphatase breaks down into phosphoric acid and 3-hydroxypyridine; 2the metabolite is formed in large quantities and is found in the urine on 1-2 day of drug administration is pharmacologically active; The 3rd metabolite is also excreted in large quantities with urine; The 4th and 5th metabolites are glucuronconjugates.

    Indications:

    Mexidant® is prescribed as a part of complex therapy with:

    - acute disturbance of cerebral circulation;

    - craniocerebral trauma;

    - discirculatory encephalopathy;

    - vegetative-vascular dystonia;

    - neurotic disorders with anxiety syndrome;

    - intellectual-mnestichesky infringements of various genesis (including infringements of memory at persons of advanced age);

    - withdrawal of the withdrawal syndrome in alcoholism with the presence in the clinical picture of neurotic and vegetative-vascular disorders.

    Contraindications:

    - Acute violations of the liver and kidneys;

    - hypersensitivity to the drug or drug intolerance;

    - Pregnancy;

    - lactation period;

    - childhood.

    Carefully:

    Allergic diseases in the anamnesis.

    Dosing and Administration:

    Mexidant® is prescribed as a part of complex therapy by intramuscular or intravenous (jet or drip). Doses are selected individually. Begin treatment with a dose of 50-100 mg 1 -3 times a day, gradually increasing the dose to obtain a therapeutic effect. Duration of treatment and the choice of individual dose depends on the severity of the patient's condition and the effectiveness of treatment. The maximum daily dose is 800 mg.

    Streaming Mexident® is administered for 5-7 minutes. For infusion introduction the drug is diluted in 200 ml of physiological 0.9% solution of sodium chloride, drip- at a rate of 60 drops per minute.

    In the treatment acute disorders of cerebral circulation Mexidant® is prescribed in the first 7-8 days at a dose of 200-300 mg once a day intravenously (drip), and then intramuscularly 100 mg 3 times a day.

    When traumatic lesions of the central nervous system Mexidant® is administered intravenously (drip) at a dose of 400-600 mg per day for 7-8 days, followed by continued intramuscular injection of 300 mg per day for 10-14 days.

    When discirculatory encephalopathy in the phase of decompensation Mexidant® is administered intravenously in a stream or drip, in a dose of 100 mg once a day for 14 days. Then the drug is administered intramuscularly at 100 mg 2-3 times a day for the next 14 days.

    For prevention dyscirculatory encephalopathy Mexident® is administered intramuscularly in a dose 100 mg 2 once a day for 10-14 days.

    When intellectual-mnestic and cognitive disorders the drug is administered intramuscularly at a dose of 100-300 mg per day for 14 days.

    When abstinence syndrome Mexidant® is administered in a dose of 100-200 mg intramuscularly 2-3 times in day or intravenously (toapelno) 1-2 times a day.

    When neurotic disorders and vegetative-vascular dystonia the drug is administered intramuscularly at a dose of 50-400 mg per day for 14 days.

    Side effects:

    From the digestive system: rarely - nausea, dry mouth, diarrhea.

    From the central nervous system: rarely - drowsiness.

    Possible allergic reactions.

    For parenteral administration (especially in / in jet): dryness, metallic taste in the mouth, sensations of "spilling heat" throughout the body, unpleasant odor, sore throat and chest discomfort, a feeling of lack of air (usually associated with an excessively high rate of administration and short-term); with prolonged use - nausea, flatulence; sleep disturbances (drowsiness or falling asleep).

    Overdose:

    Symptoms: sleep disorders (insomnia, in some cases - drowsiness); with iv introduction - a slight and short-term (up to 1.5-2 h) increase in blood pressure.

    Treatment: as a rule, is not required - the symptoms disappear on their own within 24 hours. In severe cases with insomnia - nitrazepam 10 mg, oxazepam 10 mg or diazepam 5mg. With excessive increase in blood pressure - hypotensive drugs under the control of blood pressure.

    Interaction:

    When combined, Mexidant® enhances the effect of anticonvulsants (carbamazepine), tranquilizers (bromodihydrochlorophenyl, benzodiazepine, diazepam), antiparkinsonian agents (levodopa).

    Reduces the toxic effects of ethyl alcohol.

    Special instructions:Currently, a number of drugs with a similar active substance ethylmethylhydroxypyridine succinate, that should be taken into account when carrying out therapy for other diseases, in the treatment of which drugs with this substance can be used.
    Effect on the ability to drive transp. cf. and fur:At the beginning of the drug treatment, it is necessary to refrain from engaging in potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:Solution for intravenous and intramuscular injection, 50 mg / ml.
    Packaging:

    In ampoules of 1 ml, 2 ml, 5 ml.

    5 ampoules per contour mesh package, 1 or 2 contour squares in a pack of cardboard along with instructions for use.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003334 / 01
    Date of registration:16.03.2009 / 04.08.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:TSV FIT MEKSIDANT TOV TSV FIT MEKSIDANT TOV Russia
    Manufacturer: & nbsp
    Representation: & nbspTSV FIT MEKSIDANT TOV TSV FIT MEKSIDANT TOV Russia
    Information update date: & nbsp26.04.2018
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