Clinical and pharmacological group: & nbsp

Antihypoxants and antioxidants

Means for correcting disorders in alcoholism, toxic and drug addiction

Included in the formulation
  • Astrox
    solution w / m in / in 
    HOMEKSFARM LLC     Russia
  • Medomex®
    pills inwards 
       
  • Mexident®
    solution w / m in / in 
  • Mexidol®
    solution w / m in / in 
    FARMASOFT NPK, LLC     Russia
  • Mexidol®
    pills inwards 
    FARMASOFT NPK, LLC     Russia
  • Mexidol® FORTE 250
    pills inwards 
    FARMASOFT NPK, LLC     Russia
  • Mexicor®
    solution w / m in / in 
    EcoFarmInvest, LLC     Russia
  • Mexicor®
    capsules inwards 
    EcoFarmInvest, LLC     Russia
  • Mieleklek-Lekpharm
    solution w / m in / in 
    LEKFARM, SOOO     Republic of Belarus
  • Mexiprem ®
    solution w / m in / in 
    NIZHFARM, JSC     Russia
  • Mexiprem ®
    pills inwards 
    NIZHFARM, JSC     Russia
  • Mexinin®
    solution w / m in / in 
    BRENDFARMA, LLC     Russia
  • Metostabil
    solution w / m in / in 
    ATOLL, LLC     Russia
  • Metostabil
    pills inwards 
    ATOLL, LLC     Russia
  • MetucinWel
    solution w / m in / in 
    VELFARM, LLC     Republic of San Marino
  • Neurocardia
    solution w / m in / in 
  • Neurox®
    solution w / m in / in 
  • Proinin®
    solution w / m in / in 
  • Cerekard
    solution w / m in / in 
    EKOFARMPLUS, CJSC     Russia
  • АТХ:

    N.07.X.X   Other drugs for the treatment of diseases of the nervous system

    Pharmacodynamics:

    Pharmacological action - antioxidant, membrane stabilizing, nootropic, cerebroprotective, adaptogenic, anxiolytic.

    It inhibits lipid peroxidation, increases the activity of the antioxidant system, activates the energy-synthesizing functions of mitochondria, improves energy metabolism in the cell, helps maintain the level of macroerges, including under stress hypoxia. Activates intracellular synthesis of protein and nucleic acids, enzymatic processes of the Krebs cycle, promotes glucose utilization, synthesis and intracellular accumulation of ATP. It restores the structure and function of membranes, modulates membrane-bound enzymes, ion channels, transport systems of neurotransmitters, receptor complexes, including GABA-benzodiazepine, acetylcholine, improves synaptic transmission and interrelation of brain structures.

    Improves the metabolism and blood supply of the brain, the rheological properties of blood and microcirculation, the functioning of the immune system, suppresses platelet aggregation.It has antihypoxic, cerebroprotective, anxiolytic, anti-stress, nootropic (improving memory, attention, mental performance), antihypnotic, anti-alcohol, anticonvulsant, anti-Parkinsonian and vegetotrophic action. Reduces the level of total cholesterol and LDL and causes a regression of atherosclerotic changes in the arteries (lipid-lowering and anti-atherogenic action). Has anti-ischemic properties: improves blood flow, limits the area of ​​ischemic damage and stimulates reparative processes. Increases the resistance of the organism to the influence of extreme factors and oxygen-dependent pathological conditions such as shock, stress, sleep deprivation, hypoxia, cerebral circulation disorders, brain trauma, ischemia, electric shock, physical and mental overload, conflict situations, intoxication (ethanol and etc.). Slows down the aging process. The antialcoholic effect is manifested in the sobering effect and the weakening of motivation and is used to stop the withdrawal syndrome and treat acute poisoning. Simultaneous reception with alcohol does not exacerbate intoxication, but prevents it.Reduces resistance to psychotropic drugs and enhances their effect, which makes it possible to reduce therapeutic doses and the likelihood of developing side effects. Radioprotective properties can be used for preventive purposes with an increased degree of radiation.

    In experimental and clinical placebo-controlled studies, high efficiency of oxymethylethylpyridine succinate in the complex therapy of ischemic stroke (100-1000 mg per day intravenously drip) is shown, which is manifested by regression of consciousness disorders and signs of vasomotor instability, acceleration of recovery of motor functions.

    In children, the inclusion of the drug (10 mg / kg per day orally) in the scheme of therapy of non-paroxysmal supraventricular tachycardia and sinus node weakness syndrome increased the efficiency of treatment by an average of 20-27%.

    Pharmacokinetics:

    Absorption is fast. Biotransformation in the liver by glucuronation. Half-life when administered 4.7-5 hours. Elimination by the kidneys (0.3% for 12 hours in unchanged form, 50% for 12 hours in the form of metabolites).

    Indications:

    Injection: acute and chronic disorders of cerebral circulation, including ischemic stroke and its consequences; discirculatory encephalopathy, vegetovascular dystonia; psychosomatic diseases; neurotic and neurosis-like disorders with anxiety, fear, emotional stress; memory and attention disorders, mental disability; mental and neurological diseases in old age, atherosclerosis of cerebral vessels; relief of alcohol withdrawal syndrome, accompanied by neurosis-like and vegetative-vascular disorders; acute intoxication with antipsychotics; acute purulent-inflammatory processes of the abdominal cavity: acute necrotic pancreatitis, peritonitis (as part of complex therapy).

    Pills: ischemic heart disease (complex therapy).

    V.F10-F19.F10.3   Mental and behavioral disorders caused by alcohol use - withdrawal symptoms

    V.F40-F48.F40.0   Agoraphobia

    V.F90-F98.F90.0   Violation of activity and attention

    VI.G20-G26.G24   Dystonia

    VI.G90-G99.G93.4   Encephalopathy, unspecified

    IX.I60-I69.I63   Cerebral infarction

    IX.I60-I69.I67.2   Cerebral atherosclerosis

    IX.I60-I69.I69   Effects of cerebrovascular disease

    XIX.T36-T50.T43.4   Poisoning with neuroleptics-derivatives of the phenothiazine series of butyrophenone and thioxanthene

    Contraindications:

    Hypersensitivity to oxymethylethyl pyridine succinate and / or pyridoxine, acute violations of liver and kidney function, pregnancy, breast-feeding. Contraindicated in children under 1 year.

    Carefully:

    Children under 18 years of age (safety and efficacy not determined).

    Pregnancy and lactation:

    Category of recommendations for FDA is not defined. Contraindicated (sufficient clinical experience in pregnancy and during breastfeeding is not available).

    Dosing and Administration:

    Parenterally: intramuscularly or intravenously (drip or drip).

    Intravenously spray (for 5-7 minutes) or drip (40-60 drops per minute), a physiological solution of sodium chloride is used as the solvent. The dosage regimen is selected individually. The initial dose of 50-100 mg 1-3 times a day, then the dose is gradually increased to obtain a therapeutic effect. The maximum dose is up to 800 mg per day.

    Acute disorders of cerebral circulation: as part of complex therapy - intravenously drip 200-300 mgper day in the first 2-4 days, then intramuscularly at 100 mg 3 times a day. Duration of treatment is 10-14 days.

    Dyscirculatory encephalopathy (decompensation phase): intravenously spray or drip, 100 mg 2-3 times a day for 14 days, then continue intramuscular injection of 100 mg per day for 14 days. Prevention of discirculatory encephalopathy: intramuscularly at 100 mg twice a day for 10-14 days.

    Light cognitive impairment in elderly patients, anxiety disorders: intramuscularly 100-300 mg per day for 14-30 days.

    Abstinence syndrome: 100-200 mg intramuscularly 2-3 times a day or intravenously drip 1-2 times a day for 5-7 days.

    Acute intoxication with neuroleptics: intravenously 50-300 mg per day for 7-14 days.

    Acute pancreatic necrosis, peritonitis: used in the pre- and postoperative period, the dosage regimen depends on the prevalence of the process, the severity of the condition.

    Inside: 0.1 g 3 times a day. The duration of the course is at least 2 months. Repeated courses - on the advice of a doctor.

    Side effects:

    Nausea, dry mouth, allergic reactions, diarrhea.

    Overdose:

    Symptoms: sleep disturbance (insomnia, in some cases - drowsiness); with intravenous administration - an insignificant and short-term (up to 1.5-2 h) increase in blood pressure.

    Treatment: as a rule, is not required - the symptoms of sleep disturbance disappear on their own within 24 hours. In severe cases with insomnia it is recommended to take sleeping pills. With excessive increase in blood pressure - antihypertensive drugs under the control of blood pressure.

    Interaction:

    Strengthens the action of benzodiazepine anxiolytics, antiparkinsonics and carbamazepine; strengthens the action of nitrates.

    Reduces the toxic effect of ethyl alcohol.

    Special instructions:

    With caution apply during work drivers of vehicles and people whose profession is associated with increased concentration of attention.

    Instructions
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