Mexidol® FORTE 250 is an inhibitor of free radical processes, a membrane protector possessing antihypoxic, stress-protective, nootropic, anti-epileptic and anxiolytic action. It belongs to the class of 3-hydroxypyridines.
Mechanism of action Mexidol FORTE 250 is due to its antioxidant, antihypoxic and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, improves the structure and function of the cell membrane.The drug modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, gamma-aminobutyric acid (GABA), acetylcholine), which enhances their ability to bind to ligands, contributes to the preservation of the structurally functional organization of biomembranes, neurotransmitter transport and improvement synaptic transmission. Meksidol® FORTE 250 increases the content of dopamine in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under conditions of hypoxia with an increase in the content of adenosine triphosphate (ATP) and creatine phosphate, activation of the energy-synthesizing functions of the mitochondria.
Increases the resistance of the body to the effects of various damaging factors in pathological conditions (hypoxia and ischemia, cerebral circulation, ethanol intoxication and antipsychotic drugs).
In conditions of a critical decrease in coronary blood flow, it helps maintain the structural and functional organization of cardiomyocyte membranes,stimulates the activity of membrane enzymes - phosphodiesterase, adenylate cyclase, acetylcholinesterase. It supports the activation of aerobic glycolysis in acute ischemia and promotes the restoration of mitochondrial oxidation-reduction processes under conditions of hypoxia, increases the synthesis of ATP and creatine phosphate. Ensures the integrity of the morphological structures and physiological functions of the ischemic myocardium. It improves the clinical course of myocardial infarction, improves the effectiveness of therapy, reduces the incidence of arrhythmias and intracardiac conduction disorders. Normalizes metabolic processes in ischemic myocardium, increases the antianginal activity of nitrates, improves rheological properties of blood, reduces the effects of reperfusion syndrome in acute coronary insufficiency.
Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.
It improves the metabolism and blood supply of the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation.Stabilizes the membrane structures of blood cells (erythrocytes and platelets), reducing the likelihood development of hemolysis. Has a hypolipidemic effect, reduces the content of total cholesterol and low-density lipoproteins.
Anti-stress action is manifested in the normalization of post-stress behavior, somatogenetic disorders, restoration of sleep-wake cycles, disrupted learning and memory processes, and reduction of dystrophic and morphological changes in various structures of the brain.
Mexidol® FORTE 250 has a pronounced antitoxic effect on withdrawal symptoms. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, vegetative functions, and is also capable of removing cognitive impairments caused by prolonged intake of ethanol and its cancellation. Under the influence of the drug, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which helps to reduce their doses and reduce side effects.
Mexidol® FORTE 250 improves the functional state of the ischemic myocardium.In the context of coronary insufficiency increases collateral blood flow to ischemic myocardium, it helps to preserve the integrity of cardiomyocytes and maintaining their functional activity. Effectively restores myocardial contractility with reversible cardiac dysfunction.