Active substanceEthyl methylhydroxypyridine succinateEthyl methylhydroxypyridine succinate
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  • Dosage form: & nbspfilm-coated tablets
    Composition:

    1 tablet contains:

    active substance: ethylmethylhydroxypyridine succinate in terms of 100% substance 0.125 g;

    excipients (tablet core): kaolin 0.00247 g, carboxymethyl starch sodium 0.01258 g, cellulose microcrystalline 0.11135 g, povidone 0.0134 g, talc 0.0053 g, calcium stearate 0.00275 g;

    Excipients (shell): hypromellose 0.00495 g, macrogol 0.00128 g, titanium dioxide 0.00165 g, talc 0.00037 g.

    Description:Tablets are round, biconcave, film-coated, from white to white with a creamy shade of color, on the fracture - from white to white with a grayish or yellowish or creamy shade of color.
    Pharmacotherapeutic group:Antioxidant
    ATX: & nbsp

    N.07.X.X   Other drugs for the treatment of diseases of the nervous system

    Pharmacodynamics:

    Mexiprem® refers to heteroaromatic antioxidants. Has a wide range of pharmacological activity: increases the resistance of the body to stress, shows an anxiolytic effect, not accompanied by a muscle relaxant effect; has nootropic properties, prevents and reduces learning and memory disruptions arising from aging and exposure to variouspathogenic factors; has an anticonvulsant effect; exhibits antioxidant and antihypoxic properties; increases concentration and efficiency; alleviates the toxic effects of alcohol.

    The drug improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood, reduces the aggregation of platelets. Stabilizes the membrane structures of blood cells (erythrocytes and platelets). Has a hypolipidemic effect, reduces the content of total cholesterol and low-density lipoproteins.

    The mechanism of action of Mexiprim® is due to its antioxidant and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structurally functional organization of biomembranes,transport of neurotransmitters and improvement of synaptic transmission. Mexiprim® increases the content of dopamine in the brain. It causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under conditions of hypoxia with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

    Pharmacokinetics:

    Mexiprem ® is rapidly absorbed from the gastrointestinal tract with a half-absorption period of 0.08-0.1 hours. The time to reach the maximum concentration in the blood plasma is 0.46-0.5 hours. The maximum concentration of Mexicum ® in the blood plasma is in the range of 50 to 100 ng / ml.

    The half-life of Mexuprem® and the average retention time in the body are 4.7-5 hours and 4.9-5.2 hours, respectively. Mexiprem ® in the human body is intensively metabolized with the formation of its glucuronoconjugated product. On average, for 12 hours with urine excreted 0.3% unchanged drug and 50% in the form of glucuronoconjugate from the administered dose. Most intensively, Mexiprim® and its glucuronoconjugate are excreted within the first 4 hours after taking the drug.The urinary excretion of Mexiprim® and its conjugated metabolite have significant individual variability.

    Indications:

    - Anxiety disorders in neurotic and neurosis-like states;

    - vegetative-vascular dystonia;

    - light cognitive disorders of various genesis (with psycho-organic syndrome and asthenic disorders due to acute and chronic disorders of cerebral circulation, craniocerebral trauma, neuroinfections and intoxications, senile and atrophic processes);

    - memory disorders and intellectual insufficiency in the elderly;

    - the impact of extreme (stressor) factors;

    - alcoholic abstinence syndrome with a predominance of neurosis-like and vegetative-vascular disorders.

    Contraindications:

    Hepatic and / or renal failure, increased individual sensitivity to the drug, child age, pregnancy, breastfeeding.

    Dosing and Administration:

    Mexipur® designate inside. Applied therapeutic doses and duration of treatment are determined by the sensitivity of patients to the drug.Begin treatment with a dose of 0.25-0.5 g; the average daily dose is 0.25-0.5 g, the maximum daily intake is 0.8 g. The daily dose of the drug is divided into 2-3 doses during the day.

    For the treatment of patients with anxiety disorders, vegetative-vascular dysfunctions and cognitive impairment Mexiprem ® is used for 2-6 weeks.

    When cupping alcohol withdrawal syndrome Mexiprem® is used for 5-7 days.

    Course therapy Mexiprim® is terminated gradually, reducing the dose of the drug within 2-3 days.

    Side effects:

    Rarely - nausea, dryness of the oral mucosa, drowsiness, allergic reactions.

    Overdose:

    Symptoms: violation of sleep (insomnia, in some cases - drowsiness).

    Treatment: as a rule, is not required - the symptoms disappear on their own within 24 hours. In severe cases with insomnia, it is recommended to take nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg.

    Interaction:

    Mexiprem ® is compatible with psychotropic drugs; enhances the action of benzodiazepine anxiolytics, antiparkinsonics and carbamazepine.

    Reduces the toxic effect of ethyl alcohol.

    Effect on the ability to drive transp.cf. and fur:

    During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Tablets, film-coated, 125 mg.
    Packaging:

    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

    For 1, 2, 3, 4 or 6 contour squares, together with the instructions for use, are placed in a cardboard box.

    Storage conditions:

    In a dry, the dark place at a temperature of no higher than 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiration date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001916 / 02
    Date of registration:10.09.2008 / 18.05.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Representation: & nbspNizhpharm, JSCNizhpharm, JSCRussia
    Information update date: & nbsp27.04.2018
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