In / m or in / in (jet or drip). With the infusion method of administration, the drug should be diluted in a 0.9% solution of sodium chloride.
Jet Meadol® is injected slowly for 5-7 minutes, drip - at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 1200 mg.
In acute disorders of cerebral circulation Mexidol® is used in the first 10-14 days - in / in the drip for 200-500 mg 2-4 times a day, then in / m 200-250 mg 2-3 times a day for 2 weeks.
In case of craniocerebral trauma and consequences of craniocerebral injuries Meksidol® is used for 10-15 days in / in a drop of 200-500 mg 2-4 times a day.
With discirculatory encephalopathy in the phase of decompensation Meksidol® should be administered intravenously or in droplet in a dose of 200-500 mg 1- 2 times a day for 14 days. Then in / m at 100-250 mg / day. for the next 2 weeks.
For the course of prophylaxis of dyscirculatory encephalopathy the drug is given in / m in a dose of 200-250 mg twice a day for 10-14 days.
With mild cognitive impairment in elderly patients and with anxiety disorders the drug is used in / m in a daily dose 100-300 mg / day for 14-30 days.
With acute myocardial infarction as part of complex therapy Mexidol® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy of myocardial infarction, including nitrates, beta-adrenoblockers, inhibitors angiotensin-converting enzyme (ACE), thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic drugs according to indications.
In the first 5 days to achieve maximum effect, the drug is preferably administered intravenously, in the following 9 days Mexidol® can be administered intramuscularly. Intravenous administration of the drug is carried out by dropwise infusion, slowly (to avoid side effects) on a 0.9% solution of sodium chloride or 5% dextrose (glucose) solution in a volume of 100-150 ml for 30-90 min. If necessary, a slow jet injection of the drug, which lasts at least 5 minutes, is possible.
Administration of the drug (intravenous or intramuscular) is carried out 3 times a day, every 8 hours. The daily therapeutic dose is 6-9 mg / kg body weight per day, single dose - 2-3 mg / kg body weight. The maximum daily dose should not exceed 800 mg, single dose - 250 mg.
With open-angle glaucoma of various stages in the complex therapy Meksidol® is administered intramuscularly at 100-300 mg / day, 1-3 times a day for 14 days.
With abstinence alcohol syndrome Meksidol® is administered in a dose of 200-500 mg IV drip or in / m 2-3 times a day per day for 5-7 days.
When acute intoxication with antipsychotic agents the drug is administered iv in a dose of 200-500 mg / day for 7-14 days.
In acute purulent-inflammatory processes of the abdominal cavity (acute necrotic pancreatitis, peritonitis) the drug is prescribed on the first day in both the preoperative and postoperative period. The administered doses depend on the form and severity of the disease, the prevalence of the process, the variants of the clinical course. The drug should be phased out only after a stable positive clinical and laboratory effect.
In acute edematous (interstitial) pancreatitis Mexidol® is prescribed 200-500 mg 3 times a day, iv drip (0.9% solution of sodium chloride) and in / m.
Light severity of necrotic pancreatitis - 100-200 mg 3 times a day in / in the drip (in a 0.9% solution of sodium chloride) and in / m.
Medium severity - 200 mg 3 times a day, in / in the drip (in a 0.9% solution of sodium chloride).
Heavy current - in a pulsed dosage of 800 mg in the first day, with a two-fold mode of administration; further on 200-500 mg 2 times a day with gradual decrease in a daily dose.
Extremely heavy current - in the initial dosage of 800 mg / day until the stable relief of pancreatogenic shock, to stabilize the state 300-500 mg 2 times a day in / drip (in a 0.9% solution of sodium chloride) with a gradual decrease in daily dosage.