Cytostatic therapy
The choice of dosage regimen is determined by the emetogenicity of antitumor therapy.
For adults The daily dose, as a rule, is 8-32 mg, the following regimens are recommended.
With moderate emetogenic chemotherapy or radiotherapy:
- 8 mg intravenously struino slowly or intramuscularly, immediately before the start of therapy.
With highly emeticogenic chemotherapy:
- 8 mg intravenously struino slowly just before the start of chemotherapy, and then two more intravenous injections of 8 mg, each of which is carried out in 2-4 hours;
- continuous 24-hour infusion of the drug at a dose of 24 mg at a rate of 1 mg / h;
- 16-32 mg, diluted in 50-100 ml of the appropriate infusion solution, as a 15-minute infusion, immediately before the start of chemotherapy.
The efficacy of ondansetron can be increased by a single intravenous injection of a glucocorticoid (eg, 20 mg of dexamethasone phosphate sodium salt) prior to chemotherapy.
Children
Children older than 2 years of the drug is administered at a dose of 5 mg / m2 surface of the body intravenously, immediately before the start of chemotherapy followed by oral administration at a dose of 4 mg after 12 hours.
Prevention of postoperative nausea and vomiting
Adults introduce a single dose of 4 mg intramuscularly or intravenously struino, slowly at the beginning of anesthesia.
For relief of nausea and vomiting it is recommended intramuscular or slow intravenous injection of 4 mg of the drug.
Intramuscularly in the same body region ondansetron can be administered at a dose not exceeding 4 mg!
Children to prevent postoperative nausea and vomiting ondansetron is applied in a single dose of 0.1 mg / kg (maximum to 4 mg) in the form of a slow intravenous injection before or after anesthesia.
To treat the development of postoperative nausea and vomiting in children, a slow intravenous injection of a single dose of the drug 0.1 mg / kg (maximum 4 mg) is recommended.
With regard to the prevention and treatment of postoperative nausea and vomiting in children under the age of 2 years there is no sufficient experience.
Elderly patients
Dosage adjustments are not required.
Patients with kidney and liver lesions
With renal damage, the usual daily dose and frequency of administration of the drug is not required.
With liver damage significantly reduces the clearance of ondansetron, and the half-life of it is increased from the plasma, so it is necessary to reduce the dose to 8 mg per day.
To dilute the injection solution, the following solutions can be used:
0.9% solution of sodium chloride,
5% glucose solution, Ringer's solution,
0.3% potassium chloride solution and 0.9% sodium chloride solution,
0.3% potassium chloride solution and 5% glucose solution.