In oncological practice for the prevention and reduction of the emetic syndrome in the conduct of radio and chemotherapy:
Cytostatic therapy
The choice of dosage regimen is determined by the emetogenicity of antitumor therapy.
For of adults the daily dose, as a rule, is 8-32 mg, the following regimens are recommended:
With moderate emetogenic chemotherapy or radiotherapy:
- 8 mg intravenously struino slowly or intramuscularly, immediately before the start of therapy.
With highly emeticogenic chemotherapy:
- 8 mg intravenously struino slowly just before the start of chemotherapy, and then two more intravenous injections of 8 mg, each of which is carried out in 2-4 hours;
- continuous 24-hour infusion of the drug at a dose of 24 mg at a rate of 1 mg / h;
- A 15-minute infusion of the drug in a dose of 16-32 mg, diluted in 50-100 ml of the appropriate infusion solution, immediately before the start of chemotherapy.
The effectiveness of the drug Latran® can be enhanced by a single intravenous injection of a glucocorticosteroid (eg, 20 mg dexamethasone) prior to chemotherapy.
Children over 2 years old the drug is given in a dose of 5 mg / m2 body surface intravenously, immediately before the start of chemotherapy, followed by oral administration at a dose of 4 mg after 12 hours; after the end of chemotherapy, it is recommended to continue treatment at 4 mg twice daily for 5 days.
In surgical practice for prevention and cupping an emetic postoperative syndrome:
Prevention of postoperative nausea and vomiting
Adults inject a single dose of 4 mg intramuscularly or intravenously struino, slowly at the beginning of anesthesia, or prescribe 16 mg orally 1 hour prior to the onset of anesthesia.
For relief of nausea and vomiting It is recommended a single intramuscular or slow intravenous injection of 4 mg of the drug.
Intramuscularly in the same body area, Latran® can be administered at a dose not exceeding 4 mg! Children to prevent postoperative nausea and vomiting
Latran® is used exclusively parenterally in a single dose of 0.1 mg / kg (maximum to 4 mg) in the form of a slow intravenous injection before or after anesthesia.
To treat the development of postoperative nausea and vomiting in children a slow intravenous single dose is recommended
of the drug Latran® 0.1 mg / kg (maximum to 4 mg). With regard to the prevention and treatment of postoperative nausea and vomit in children under 2 years of age there is no sufficient experience.
For symptomatic treatment of alcohol withdrawal syndrome the drug is administered intravenously drip in a dose of 8 mg in 400 ml of potassium solution chloride + sodium acetate + sodium chloride (Chlosol) or 0.9% solution sodium chloride. If necessary, repeated administration is possible preparation of Latran®.
Elderly patients
Dosage adjustments are not required.
Patients with kidney and liver lesions
In renal pathology, change the usual daily dose and frequency administration of the drug is not required.With liver pathology, the daily dose is reduced to 8 mg.
For the dilution of the injection solution, the following solutions:
- 0.9% solution of sodium chloride,
- 5% dextrose solution,
- Ringer's solution,
- 0.3% potassium chloride solution and 0.9% sodium chloride solution,
- 0.3%) potassium chloride solution and 5% dextrose solution.
The infusion solution should be prepared immediately before use.