Cytostatic therapy
The choice of the dosage regimen is determined by the severity of the emetogenic effect of the antitumor therapy.
For adults daily dose, as a rule, is 8-32 mg, the following regimens are recommended:
With moderately-emetogenic chemotherapy or radiotherapy:
8 mg ondansetron inside for 1-2 hours before the start of the main therapy with subsequent 8 mg orally through 12 h.
With highly emeticogenic chemotherapy:
The recommended dose of ondansetron is 24 mg concurrently with dexamethasone inside at a dose 12 mg for 1-2 hours before the start of chemotherapy.
To prevent late or prolonged vomiting that occurs after 24 hours, continue taking ondansetron in a dose 8 mg twice daily for 5 days.
Children
Children older than 3 years of the drug is administered at a dose of 5 mg / m2 the surface of the body intravenously, immediately before the start of chemotherapy, followed by ingestion of 4 mg after 12 hours; treatment is recommended to continue at a dose of 4 mg 2 times a day inside for 5 days.
Prevention of postoperative nausea and vomiting
Adults prescribe 16 mg orally 1 hour before the onset of general anesthesia.
Children to prevent postoperative nausea and vomiting ondansetron is used exclusively parenterally.
Patients of elderly growth
Dosage adjustments are not required.
Patients with impaired renal function
Change the usual daily dose and the frequency of administration of the drug is not required.
Patients with impaired hepatic function
With moderate or severe violations of liver function, the clearance of ondansetron significantly decreases,This increases the half-life of it from the plasma, so it is not recommended for such patients to prescribe more 8 mg ondansetron per day.