Cytostatic therapy
The choice of the dosage regimen is determined by the severity of the emetogenic effect of the antitumor therapy.
For adults The daily dose is 8-32 mg / day, the following regimens are recommended. With moderately-emetogenic chemotherapy or radiotherapy:
8 mg intravenously struino slowly or intramuscularly, immediately before the start of therapy.
With highly emeticogenic chemotherapy:
-8 mg intravenously struino slowly just before the start of chemotherapy, then two more intravenous injections of 8 mg, each of which is carried out in 2-4 hours;
-continuous 24-hour infusion of the drug at a dose of 24 mg at a rate of 1 mg / h;
-16-32 mg, diluted in 50-100 ml of the appropriate infusion solution, as a 15-minute infusion, immediately before the start of chemotherapy.
The efficacy of Odansetron can be increased by a single intravenous injection of glucocorticosteroids (eg, 20 mg dexamethasone) prior to chemotherapy.
To prevent delayed vomiting that occurs 24 hours after the onset of chemo- or radiotherapy - both with the use of high-emetogenic therapy, and with moderate-emetogenic therapy - it is recommended to continue using the drug inside as tablets at 8 mg 2 times a day for 5 days.
Children
Children older than 2 years of the drug is administered at a dose of 5 mg / m2 the surface of the body intravenously, immediately before the start of chemotherapy, followed by ingestion of 4 mg after 12 hours; treatment is recommended to continue at a dose of 4 mg 2 times a day inside for 5 days.
Prevention of postoperative nausea and vomiting
Adults inject a single dose of 4 mg intramuscularly or intravenously slowly at the onset of anesthesia.
For relief of nausea and vomiting it is recommended intramuscular or slow intravenous injection of 4 mg of the drug.
Intramuscularly in the same body region ondansetron can be administered at a dose not exceeding 4 mg!
Children to prevent postoperative nausea and vomiting ondansetron is used exclusively parenterally in a single dose of 0.1 mg / kg (maximum to 4 mg) in the form of a slow intravenous injection before or after anesthesia.
To treat the development of postoperative nausea and vomiting in children, a slow intravenous injection of a single dose of the drug 0.1 mg / kg (maximum 4 mg) is recommended.
In the prevention and treatment of postoperative nausea and vomiting in children under 2 years of age, there is no sufficient experience.
Elderly patients Dosage adjustments are not required.
Patients with impaired renal function
Change the usual daily dose and the frequency of administration of the drug is not required.
Patients with impaired hepatic function
With moderate or severe impairment of liver function, the clearance of ondansetron is significantly reduced, while the half-life of it is increased from the plasma, so it is not recommended for such patients to prescribe more than 8 mg of ondansetron per day.
To dilute the injection solution, the following solutions can be used:
0.9% solution of sodium chloride,
5% dextrose solution, Ringer's solution,
0.3% potassium chloride solution and 0.9% sodium chloride solution,
0.3% potassium chloride solution and 5% dextrose solution.