Cytostatic therapy
The choice of dosage regimen is determined by the emetogenicity of antitumor therapy.
For adults The daily dose, as a rule, is 8-32 mg.
The following modes are recommended.
With moderate emetogenic chemotherapy or radiotherapy:
8 mg intravenously struino slowly or intramuscularly, immediately before the start of therapy;
With highly emeticogenic chemotherapy:
- 8 mg intravenously struino slowly just before the start of chemotherapy, and then two more intravenous injections of 8 mg, each of which is carried out in 2-4 hours;
- continuous 24-hour infusion of the drug at a dose of 24 mg at a rate of 1 mg / h;
-16-32 mg, diluted in 50-100 ml of the appropriate infusion solution, in the form of a 15-minute infusion, just before the start of chemotherapy. The efficacy of ondansetron can be increased by a single intravenous injection of a glucocorticoid (eg, 20 mg dexamethasone) before the onset
chemotherapy.
To prevent delayed vomiting. arising after 24 hours from the beginning chemotherapy or radiotherapy - as with the use of highly emetogenic therapy, and with moderately-emetogenic therapy - it is recommended to continue the use of the drug inside in the form of tablets of 8 mg 2 times a day for 5 days.
Children
Children older than 2 years of the drug is administered at a dose of 5 mg / m body surface intravenously, immediately before the start of chemotherapy.
Prevention of postoperative nausea and vomiting
Adults introduce a single dose of 4 mg intramuscularly or intravenously struino, slowly at the beginning of anesthesia.
For relief of nausea and vomiting it is recommended intramuscular or slow intravenous injection of 4 mg of the drug.
Intramuscularly in the same body region ondansetron can be administered at a dose not exceeding 4 mg!
Children to prevent postoperative nausea and vomiting ondansetron is used exclusively parenterally in a single dose of 0.1 mg / kg (maximum to 4 mg) in the form of a slow intravenous injection before, during or after anesthesia. To treat the development of postoperative nausea and vomiting in children, a slow intravenous injection of a single dose of the drug 0.1 mg / kg (maximum 4 mg) is recommended.
With regard to the prevention and treatment of postoperative nausea and vomiting in children under 2 years of age there is no sufficient experience.
Elderly patients Dosage adjustments are not required.
Patents with impaired renal function
With renal damage, the usual daily dose and frequency of administration of the drug is not required.
Patients with impaired hepatic function
With moderate or severe impairment of liver function, the clearance of ondansetron is significantly reduced, while the half-life of it is increased from the plasma, so it is not recommended for such patients to prescribe more than 8 mg of ondansetron per day.
To dilute the injection solution, the following solutions can be used:
- 0.9% solution of sodium chloride,
- 5% glucose solution,
- Ringer's solution,
- 0.3% potassium chloride solution and 0.9% sodium chloride solution,
- 0,3 % potassium chloride solution and 5% glucose solution.