Unitiol - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Complexing agent, has detoxification effect. Active sulfhydryl groups Unithiol, reacting with thiol poisons (arsenic compounds, heavy metal salts) and forming with them non-toxic, water-soluble compounds, restore the functions of the enzyme systems of the organism affected by poison.With diabetic polyneuropathy reduces pain syndrome, improves the condition of the peripheral nervous system and normalizes the permeability of capillaries.

Pharmacokinetics:When parenteral administration is rapidly absorbed into the blood. The maximum concentration in the blood plasma is reached after 15-30 minutes after intramuscular injection. Half-life is 1-2 hours. Excreted by the kidneys, mainly as products of incomplete and complete oxidation, in part - in an unchanged form.

Indications:Intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides, hepatocerebral dystrophy (Wilson-Konovalov's disease), diabetic polyneuropathy, chronic alcoholism (as part of complex therapy), delirious psychosis.

Contraindications:Hypersensitivity to the drug, liver failure; arterial hypertension.

Dosing and Administration:

Intramuscularly, subcutaneously.

- with intoxication with arsenic and mercury compounds: 250-500 mg (at the rate of 5 mg / kg of body weight), on the first day - 3-4 times, on the second day - 2-3 times, in the subsequent - 1-2 times. Treatment is carried out until the signs of intoxication disappear.

- with intoxication with cardiac glycosides: the first 2 days 250-500 mg 3-4 times a day, then 1 -2 times a day until the cardiotoxic action is terminated.

- with hepatocerebral dystrophy: intramuscularly 250-500 mg daily or every other day; course of treatment - 25-30 injections; if necessary, repeat after 3-4 months.

- at a chronic alcoholism appoint 150-250 mg 2-3 times a week. At delirium - once injected 200-250 mg.

- with diabetic polyneuropathy - intravenously, 250 mg, the course of treatment - 10 injections.

Side effects:Nausea, dizziness, tachycardia, pallor of the skin, allergic reactions.

Overdose:Symptoms: increased severity of side effects. Treatment: symptomatic.

Interaction:Pharmaceutically incompatible with alkalis (rapidly decomposes) and preparations containing heavy metals.

Form release / dosage:Solution for intramuscular and subcutaneous administration 50 mg / ml.

Packaging:A solution for intramuscular and subcutaneous administration of 50 mg / ml in 5 ml ampoules. 10 ampoules in a carton box or 5 ampoules in a planar cell pack. 2 contour packs in a cardboard bundle. The instructions for use are enclosed in a box and a pack, an ampoule knife or a scarifier ampoule (when packing ampoules with notches, rings and dots, ampoules or scarifiers do not invest).

Storage conditions:List B. In a place protected from light, inaccessible to children, at a temperature of no higher than 25 ° C.

Shelf life:5 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-003455/07

Date of registration:29.10.2007

The owner of the registration certificate:PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia

Information update date: & nbsp25.01.2016

Illustrated instructions

Instructions

Unithiol (Unithiol)