Unithiol-Ferein (Unithiol-Ferein)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium dimercaptopropanesulfonateSodium dimercaptopropanesulfonate
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    solution
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    • Dosage form: & nbspSolution for intramuscular and subcutaneous injection.
    Composition:
    Active substance - unitiol 0.05 g in 1 ml of solution

    Excipients: water for injection.
    Description:
    Transparent colorless or pinkish liquid with a faint smell of hydrogen sulfide.

    Pharmacotherapeutic group:Complexing agent.
    ATX: & nbsp

    V.03.A.B   Antidotes

    Pharmacodynamics:Complexing agent, has detoxification effect. The active sulfhydryl groups of unithiol, reacting with thiol poisons (arsenic compounds, heavy metal salts) and forming with them nontoxic, water-soluble compounds, restore the functions of the enzyme systems of the organism affected by the poison.With diabetic polyneuropathy reduces pain syndrome, improves the condition of the peripheral nervous system and normalizes the permeability of capillaries.
    Pharmacokinetics:

    When parenteral administration is rapidly absorbed into the blood. The maximum level of the drug in the blood (CmOh) is achieved after 15-30 minutes after an / m injection. Half-life (T1/2) -1-2 hours Excreted by the kidneys, mainly as products of incomplete and complete oxidation, partially in an unchanged form.

    Indications:Intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides, hepatocerebral dystrophy (Wilson-Konovalov's disease), diabetic polyneuropathy, chronic alcoholism (as part of complex therapy), delirium,
    Contraindications:Hypersensitivity to the drug, liver failure; arterial hypertension.
    Dosing and Administration:
    Intramuscularly, subcutaneously. In case of arsenic intoxication - 5-10 ml of the drug (at the rate of 0.005 g / 1 kg), on the first day - 3-4 times, on the second day - 2-3 times, in the subsequent - 1-2 times. When poisoning with mercury compounds - according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear.
    With digitalis intoxication, in the first 2 days 5-10 ml of 5% aqueous solution is administered 3-4 times a day, then 1-2 times a day until the cardiotoxic effect stops. With hepatocerebral dystrophy - in / m 5-10 ml of 5% solution daily or every other day; course of treatment - 25-30 injections; if necessary, repeat after 3-4 months. With chronic alcoholism prescribe 3-5 ml 2-3 times a week. For relief of delirium-one-time 4-5 ml of solution.
    Side effects:
    Nausea, dizziness, tachycardia, pale skin.
    Allergic reactions are possible.
    Overdose:In the recommended doses and on the evidence of overdose phenomena does not arise.
    Interaction:It is not recommended simultaneous use of unithiol with drugs, which include heavy metals and alkalis, t. there is a rapid decomposition of unithiol.
    Special instructions:In acute poisoning, along with the administration of the drug, gastric lavage, oxygen therapy, glucose administration, etc. are performed.
    Form release / dosage:5% solution for intramuscular and subcutaneous injection.
    Packaging:5% solution for intramuscular and subcutaneous injections in 5 ml ampoules, 5 ampoules per contour cell package, 1 or 2 contour packs per pack.
    Storage conditions:5 years. Do not use at the expiration date indicated on the package.
    Shelf life:List B. In the dark place at a temperature of not more than 20 C, out of reach of children.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002691 / 01
    Date of registration:07.10.2008
    The owner of the registration certificate:BRYNTSALOV-A, CJSC BRYNTSALOV-A, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.01.2016
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