Unitiol - instructions for use, dose, side effects, contraindications

Complexing agent, has detoxification effect. Active sulfhydryl groups, reacting with thiol poisons (arsenic compounds, heavy metal salts) and forming non-toxic water-soluble compounds with them, restore the functions of the enzyme systems of the organism affected by poison.Increases the excretion of certain cations (especially copper and zinc) from metal-containing cell enzymes.

Pharmacokinetics:

When parenteral administration is rapidly absorbed into blood.

The maximum concentration in blood plasma (C max) toflashes after 15-30 miafter intramuscular injection. Half-life (T1 / 2) 1-2 hours. Volume of distribution - 166.5 ml / kg. The drug is distributed, mainly in the aqueous phase (blood plasma). The drug is widely distributed in the tissues of the body, the highest concentrations found in the kidneys and liver. Do not cumulate.

Excreted by the kidneys, mainly in the form of incomplete and complete oxidation products, partially unchanged. Excreted also with bile. Eliminated within 4 hours after applying a single dose.

Indications:

Intoxication with arsenic, mercury, bismuth, chromium, gold, antimony, thallium and cardiac glycosides;

hepatocerebral dystrophy (Wilson-Westfal-Konovalov disease);

chronic alcoholism (as part of complex therapy), alcohol delirium (as part of complex therapy).

Contraindications:

Hypersensitivity to the components of the drug, liver failure, hypertension, pregnancy, the period of breastfeeding, children under 18 years.

With the development of renal failure, the drug should be discontinued or applied with extreme caution.

Carefully:

Long-term use of the drug should be carried out under the constant supervision of the excretion of heavy metals by the kidneys.

Pregnancy and lactation:

The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:Intramuscularly, subcutaneously.

At an intoxication with arsenic: 250-500 mg (5-10 ml of preparation) at the rate of 50 mg / 10 kg. at the first day 3-4 times, on the second day 2-3 times, in the subsequent - on 1-2 times.

When poisoning with mercury compounds: according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear.

With digital intoxication: in the first two days, 250-500 mg (5-10 ml of the drug) are administered 3-4 times a day, then 1-2 times a day until the cardiotoxic effect stops.

In hepatocerebral dystrophy: intramuscularly 250-500 mg (5-10 ml of the drug) daily or every other day: a course of treatment of 25-30 injections; if necessary, repeat after 3-4 months.

With chronic alcoholism, 150-250 mg (3-5 ml of the drug) are prescribed 2-3 times a week. For relief of delirium: once 200-250 mg (4-5 ml of the drug).

Side effects:

Allergic reactions are possible.Nausea, dizziness, tachycardia, pale skin. Increased blood pressure, vomiting, headache, burning sensation in the lips, mouth and throat, a feeling of restraint and pain in the throat, chest and hands, conjunctivitis, lacrimation, spasm of the eyelids, rhinorrhea, drooling, tingling in the hands, burning sensation in the penis , sweating of the forehead, brushes and other areas, abdominal pain, anxiety, weakness, anxiety, hemolysis, transient leukocytopenia, tremor, burning eyes, hepatotoxicity, spasms and muscle pain, jaw pain, kidney failure, hyperthermia, pain in place injections, renewal of assets th e partial thromboplastin time, reducing the concentration of zinc in the blood.

When applying high doses of the drug, a sharp increase in blood pressure with convulsions and coma may occur.

When a drug is administered in a therapeutic dose, undesirable reactions are almost always reversible and are rarely serious enough to stop treatment.

It is possible to reduce unwanted reactions while observing an interval of 4 hours between doses of the drug. If any of the side effects listed in the manual are aggravated,or you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Symptoms: malaise, nausea, vomiting, lacrimation and salivation, sensation burning lips, mouth, throat and eyes with a headache. Feeling tight in the throat and chest. Increase in blood pressure maximum after 15-20 minutes. These effects can last about four hours.

Possible treatment: subcutaneous injection of diphenhydramine 50 mg or 30 mg ephedrine.

Interaction:

It is not recommended simultaneous use of Unithiol with preparations containing heavy metals and alkalis, as the rapid decomposition of Unithiol occurs.

Special instructions:

In acute poisoning, additional therapeutic measures are carried out (gastric lavage, oxygen therapy, dextrose administration, etc.).

It is not allowed to apply simultaneously with iron preparations.

At application it is recommended alkalinization of urine, t. in an acid medium, the sodium-metal dimercaptopropanesulfonate complex is unstable.

There is insufficient evidence of the effectiveness of the drug in bismuth and antimony poisoning. The drug is effective in acute poisoning with mercury (if therapy is started within 1-2 hours after poisoning), the drug is ineffective in chronic mercury poisoning.

It is inadmissible to use the drug for iron, cadmium, selenium poisoning, since their complexes with unithiol are more toxic, especially for the kidneys.

When using Unithiol, a transient decrease in the percentage of polymorphonuclear leukocytes is possible.

In patients with deficiency of glucose-6-phosphate dehydrohepase with the use of unithiol, hemolysis is possible (which can be very serious). In patients with a high risk of glucose-6-phosphate dehydrogenase deficiency, a preliminary examination and monitoring of possible hemolysis during drug therapy is necessary.

Effect on the ability to drive transp. cf. and fur:Data confirming the influence of Uniothiol on the ability to engage in potentially hazardous activities that require increased attention, no.

Form release / dosage:

Solution for intramuscular and subcutaneous administration 50 mg / ml.

Packaging:

5 ml into neutral glass ampoules.

For 10 ampoules with instructions for use and a knife for opening ampoules or a scarifier ampullum will be placed in a box of cardboard for consumer containers.

For 5 or 10 ampoules are placed in a contour mesh box made of a polyvinyl chloride film or a polyethylene terephthalate tape andaluminum foil or paper with a polyethylene coating or without a foil, or without paper.

For 1 or 2 contour packs with the instruction for use and a knife for opening ampoules or a scarifier ampullum is placed in a pack of cardboard.

When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.

Storage conditions:

In the dark place at a temperature of 2 ° C to 25 ° C.

Keep out of the reach of children.

Shelf life:2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP 002849

Date of registration:04.02.2015

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Information update date: & nbsp28.12.15

Illustrated instructions

Instructions

Unithiol (Unithiol)