Unithiol (Unithiol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium dimercaptopropanesulfonateSodium dimercaptopropanesulfonate
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    • Dosage form: & nbspSolution for intramuscular and subcutaneous injection.
    Composition:
    1 ml contains:

    Active substance: sodium dimercaptopropanesulfonate monohydrate (unitiol) 50 mg.
    Excipients: sulfuric acid solution 0.1 M sufficient amount of pH adjustment 3.1-4.5, water for injection up to 1 ml.
    Description:Transparent colorless or pinkish liquid with a slight smell of hydrogen sulfide.
    Pharmacotherapeutic group:Complexing agent.
    ATX: & nbsp

    V.03.A.B   Antidotes

    Pharmacodynamics:Complexing agent, has detoxification effect. Active sulfhydryl groups, interacting with thiol poisons (arsenic compounds,salts of heavy metals) and forming with them non-toxic, water-soluble compounds, restore the functions of the enzyme systems of the organism affected by poison. Increases the excretion of certain cations (especially copper and zinc) from metal-containing cell enzymes.
    Pharmacokinetics:When parenteral administration is rapidly absorbed into the blood. The maximum concentration of the drug in the blood is reached after 15-30 minutes after intramuscular injection. The half-life is 1-2 hours. The volume of distribution is 166.5 ml / kg. The drug is distributed mainly in the aqueous phase (blood plasma). Do not cumulate. Excreted by the kidneys, mainly as products of incomplete and complete oxidation, in part - in unchanged form.
    Indications:Intoxication with arsenic, mercury, gold, chromium, cardiac glycosides, hepatocerebral dystrophy (Wilson-Westfal-Konovalov's disease), chronic alcoholism (as part of complex therapy), alcoholic delirium (as part of complex therapy).
    Contraindications:Hypersensitivity to the components of the drug, liver failure, hypertension, pregnancy, the period of breastfeeding, children under 18 years.With the development of renal failure, the drug should be discontinued or applied with extreme caution.
    Carefully:Long-term use of the drug should be carried out under the constant supervision of the excretion of heavy metals by the kidneys.
    Pregnancy and lactation:The drug is contraindicated in pregnancy and during breastfeeding.
    Dosing and Administration:
    Intramuscularly, subcutaneously.

    At an intoxication with arsenic - 250-500 mg (5-10 ml of preparation), at the rate of 0,05 g / 10 kg. in the first day - 3-4 times, on the second day - 2-3 times, in the next 1-2 times. When poisoning with mercury compounds - according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear.

    When digital intoxication in the first 2 days, 250-500 mg (5-10 ml of the drug) is administered 3-4 times a day, then 1-2 times a day until the cardiotoxic action stops. In hepatocerebral dystrophy - intramuscularly 250-500 mg (5-10 ml of the drug) daily or every other day; course of treatment - 25-30 injections; if necessary, repeat after 3-4 months.

    With diabetic polyneuropathy - intramuscularly 250 mg (5 ml of the drug), treatment course - 10 injections.

    With chronic alcoholism, 150-250 mg (3-5 ml of the drug) are prescribed 2-3 times a week. To relieve delirium - once 200-250 mg (4-5 ml of the drug).
    Side effects:
    Allergic reactions are possible. Nausea, dizziness, tachycardia, pale skin. Increased blood pressure, vomiting, headache, burning sensation in the lips, mouth and throat, a feeling of restraint and pain in the throat, chest and hands, conjunctivitis, lacrimation, spasm of the eyelids, rhinorrhea, drooling, tingling in the hands, burning sensation in the penis , sweating. LB, brushes and other areas, abdominal pain, anxiety, weakness, anxiety

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.
    Overdose:Symptoms: shortness of breath, hyperkinesia, inhibition, lethargy. deafness, short-term convulsions (occur when the recommended therapeutic dose is exceeded by more than 10 times).
    Treatment: symptomatic therapy.
    Interaction:It is not recommended to use simultaneously with preparations that contain heavy metals and alkalis, as the rapid decomposition of Unithiol occurs.
    Special instructions:In acute poisoning, additional therapeutic measures (gastric lavage, oxygen therapy,administration of dextrose, etc.). It is not allowed to apply simultaneously with iron preparations. Urine alkalinization is recommended.
    Effect on the ability to drive transp. cf. and fur:Does not affect.
    Form release / dosage:
    Solution for intramuscular and subcutaneous administration, 50 mg / ml.
    Packaging:
    To 5 ml in ampoules of neutral glass brand HC-1.
    For 10 ampoules, together with the instructions for medical use and the ampoule or ampoule ampoule with a knife, are put into a cardboard box.
    Storage conditions:In a dry, dark place at a temperature of no higher than 20 ° C. Keep out of the reach of children.
    Shelf life:
    5 years. Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-002147
    Date of registration:17.07.2013
    Date of cancellation:2018-07-17
    The owner of the registration certificate:StatusPharm, LLC StatusPharm, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.01.2016
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