Active substanceSodium dimercaptopropanesulfonateSodium dimercaptopropanesulfonate
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    StatusPharm, LLC     Russia
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    BRYNTSALOV-A, CJSC     Russia
  • Dosage form: & nbsp
    Solution for intramuscular and subcutaneous injection.
    Composition:
    1 ml of solution contains

    Active substance: Sodium dimercaptopropanesulfonate monohydrate (Unitiol) - 50 mg;

    Excipients: Disodium edetate (Trilon B) 0.1 mg, sulfuric acid 0.1 M to pH 3.1-4.5, water for injection up to 1 ml.
    Description:Transparent colorless or pinkish liquid with a faint smell of hydrogen sulfide.
    Pharmacotherapeutic group:Complexing agent.
    ATX: & nbsp

    V.03.A.B   Antidotes

    Pharmacodynamics:Complexing agent, has detoxification effect. Active sulfhydryl groups of Unithiol, interacting with thiol poisons (arsenic compounds,salts of heavy metals) and forming non-toxic water-soluble compounds with them, restore the functions of the enzyme systems of the body affected by poison. Increases the excretion of certain cations (especially copper and zinc) from metal-containing cell enzymes.
    Pharmacokinetics:When parenteral administration is rapidly absorbed into the blood. The maximum concentration of the drug in the blood (Cmax) is reached 15-30 minutes after intramuscular injection. The half-life (T1 / 2) is 1-2 hours.
    The volume of distribution is 166.5 ml / kg. The drug is distributed mainly in the aqueous phase (blood plasma). Do not cumulate.
    Excreted by the kidneys, mainly as products of incomplete and complete oxidation, in part - in unchanged form.
    Indications:
    Intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides; hepatocerebral dystrophy (Wilson-Westfal-Konovalov disease); chronic alcoholism (as part of complex therapy), alcoholic delirium.

    Contraindications:Hypersensitivity to the drug, liver failure, hypertension, pregnancy, lactation, children under 18 years.
    Dosing and Administration:
    Preferably intramuscularly or subcutaneously.At an arsenic intoxication - 250-500 mg (5-10 ml of an aqueous solution of 50 mg / ml), at the rate of 0.05 g / 10 kg, on the first day - 3-4 times, on the second day - 2-3 times, in the next - 1-2 times. When poisoning with mercury compounds - according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear. With digitalis intoxication, 250-500 mg (5-10 ml of an aqueous solution of 50 mg / ml) are administered 3-4 times a day in the first 2 days, then 1-2 times a day until the cardiotoxic effect stops.

    For hepatocerebral dystrophy - intramuscularly 250-500 mg (5-10 ml of a solution of 50 mg / ml) daily or every other day; course of treatment - 25-30 injections; if necessary, repeat after 3-4 months.

    In chronic alcoholism, 150-250 mg (3-5 ml of a solution of 50 mg / ml) are prescribed 2-3 times a week. For relief of delirium - once 200-250 mg (4-5 ml of a solution of 50 mg / ml).
    Side effects:Nausea, dizziness, tachycardia, pale skin. Allergic reactions are possible.
    Overdose:Symptoms: dyspnea, hyperkinesia, inhibition, lethargy, deafness, short-term convulsions (occur when the recommended therapeutic dose is exceeded by more than 10 times). Treatment: symptomatic therapy.
    Interaction:It is not recommended simultaneous use of Unithiol with preparations containing heavy metals and alkalis, as the rapid decomposition of Unithiol occurs.
    Special instructions:In acute poisoning, additional therapeutic measures are carried out (gastric lavage, oxygen therapy, dextrose administration, etc.).
    Effect on the ability to drive transp. cf. and fur:
    Solution for intramuscular and subcutaneous administration 50 mg / ml.


    Form release / dosage:
    5 ml per ampoule of neutral glass. 5 ampoules are placed in a contour mesh package made of a polyvinyl chloride film.
    2 contour mesh packages together with the instruction for use and the ampoule disk ceramic ceramic scriber are put in a pack of cardboard. When packing ampoules with a dot or a ring of fracture, the scarifier is not inserted.
    Storage conditions:
    List B. Store in a dark place at a temperature of 0 to 25 ° C.

    Do not freeze.

    Keep out of the reach of children.
    Shelf life:
    5 years.

    Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002953 / 01
    Date of registration:29.10.2008
    The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.01.2016
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