Sulfacetamide - instructions for use, dose, side effects, contraindications

Composition:Active substance: sodium sulfacetamide (in terms of 100% substance) - 200 mg. Excipients: sodium thiosulphate pentahydrate - 1 mg, 1 M solution of hydrochloric acid - up to pH 8, water for injection - up to 1 ml.

Description:Transparent colorless or light yellow liquid.

Pharmacotherapeutic group:Antimicrobial agent - sulfonamide.

ATX: & nbsp

A.07.A.B Sulfonamides

Pharmacodynamics:Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action caused by a competitive antagonism with para-aminobenzoic acid, inhibition digidropteroatsintetazy, tetrahydrofolic acid synthesis disorder necessary for the synthesis of purines and pyrimidines.

Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics:With topical application of Cmax sulfonamides in the cornea (about 3 mg / ml), the anterior chamber moisture (about 0.5 mg / ml) and iris (about 0.1 mg / ml) is achieved in the first 30 minutes after application. A certain amount (less than 0.5 mg / ml) is retained in the tissues of the eyeball for 3-4 hours with epithelial damage to the cornea, the penetration of sulfonamides is enhanced.

Indications:

As part of complex therapy in adults:

- conjunctivitis, blepharitis, purulent corneal ulcer;

- gonorrheal and chlamydial diseases of the eyes.

Prophylaxis and treatment of blenorea in newborns.

Contraindications:Hypersensitivity.

Pregnancy and lactation:Sufficient experience in the use of the drug for the treatment of pregnant women and during lactation there. It is possible to administer sulfacetamide to the doctor's prescription if the intended benefit to the mother exceeds the potential risk of the fetus or child's day.

Dosing and Administration:Locally. For the treatment of conjunctivitis in children and adults, instill 1 to 2 drops into the conjunctival sac every 2 to 3 hours. The course of treatment is 7-10 days.

For the treatment of blepharitis in children and adults, instilled in a conjunctival sac, the frequency of installations in the first days is up to 6-8 times and decreases to 3-4 times a day as the condition improves. The course of treatment is 3-5 days.

For treatment of purulent corneal ulcer as part of complex therapy in the form of installations 5-6 times a day for 5-7 days.

For the prevention of blennery in newborns - 2 drops in each conjunctival sac immediately after birth and 2 drops in 2 hours. For treatment of gonorrheal and chlamydial eye diseases in adults, as part of complex therapy, 1-2 drops 5-6 times a day, for 4-6 weeks. With positive dynamics against the background of ongoing treatment, the number of drops installations decreases every subsequent week.

Side effects:Allergic reactions, burning, lacrimation, pain, itching in the eyes, transient blurring of vision after instillation.

Overdose:Cases of overdose are not described.

Interaction:

The combined use with procaine and tetracaine reduces the bacteriostatic effect.

Incompatible with the salts of silver.

Special instructions:Patients who are hypersensitive to furosemide, thiazide diuretics, sulfonyl urea or inhibitors of carbonic anhydrase may have increased sensitivity to sulfacetamide.

Effect on the ability to drive transp. cf. and fur:Patients who temporarily lose visual clarity after application, immediately after instillation of the drug, it is not recommended to drive vehicles or work with complex equipment, machines or some other equipment that requires clear vision.

Form release / dosage:Eye drops 20%.

Packaging:

By 5 or 10 ml in polyethylene or polypropylene bottles, sealed with droppers and screw caps.

One bottle with instructions for medical use of the drug is placed in a pack of cardboard.

For 50 bottles with an equal number of instructions for medical use of the drug are placed in a box of cardboard (for hospitals).

Storage conditions:In the dark place at a temperature of no higher than 15 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001498

Date of registration:13.02.2012

Date of cancellation:2017-06-14

The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia

Manufacturer: & nbsp

ESKOM NPK, OAO Russia

Information update date: & nbsp14.06.2017

Illustrated instructions

Instructions

Sulfacetamide (Sulfacetamide)