Sulfacyl-sodium - instructions for use, dose, side effects, contraindications

Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action is due to competitive antagonism with paraaminobenzoic acid (PABA), inhibition of dihydropteroate synthetase, a violation of the synthesis of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.

Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics:Penetrates the tissues and fluid eyes. Absorbed into the systemic bloodstream through an inflamed conjunctiva. With topical application, the maximum concentration of sulfonamides in the cornea (about 3 mg / ml), the anterior chamber humidity (about 0.5 mg / ml) and the iris (about 0.1 mg / ml) is achieved in the first 30 minutes after application. Some amount (less than 0.5 mg / ml) is stored in the tissues of the eyeball for 3-4 hours. If the epithelium of the cornea is damaged, the penetration of sulfonamides is enhanced.

Indications:Conjunctivitis, blepharitis, purulent corneal ulcer, prevention and treatment of blenarus in newborns, gonorrhea and chlamydia eye diseases in adults.

Contraindications:Hypersensitivity.

Pregnancy and lactation:It is possible to use sulfacetamide to treat pregnant and lactating mothers as prescribed by the doctor if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

Dosing and Administration:Locally, instill 1-2 drops in each conjunctival sac 4-6 times a day. For the prevention of blennery in newborns - 2 drops in each conjunctival sac immediately after birth and 2 drops - after 2 hours.

Side effects:Burning, lacrimation, itching, itching in the eyes, allergic reactions.

Interaction:The combined use with procaine and tetracaine reduces the bacteriostatic effect. Incompatible with the salts of silver.

Special instructions:Patients who are hypersensitive to furosemide, thiazide diuretics, sulfonyl urea or inhibitors of carbonic anhydrase may have increased sensitivity to sulfacetamide.

Form release / dosage:Eye drops 20%.

Packaging:5 ml or 10 ml in the bottles-dropper polymer. Each vial with instructions for use is placed in a pack of cardboard. 50 bottles are placed in boxes of cardboard with the application of 5 instructions for use for delivery to hospitals.

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

2 years.

After opening the vial, use within 1 month. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N003555 / 01

Date of registration:14.05.2009

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Information update date: & nbsp03.09.2015

Illustrated instructions

Instructions

Sulfacil sodium (Sulfacyl-sodium)