Penetrates into the tissue of the eye, where it exerts its specific antibacterial effect. Acts mainly locally, but part of the drug is absorbed through the inflamed conjunctiva and enters the systemic circulation.
When topically applied, the maximum concentration (Cmax) of sulfonamides in the cornea (about 3 mg / ml), the anterior chamber humidity (about 0.5 mg / ml) and the iris (about 0.1 mg / ml) is reached 30 min after instillation.A small amount (less than 0.5 mg / ml) of sulfacetamide is retained in the tissues of the eyeball for 3-4 hours. If the epithelium of the cornea is damaged, the penetration of sulfonamides is enhanced.