Sulfacyl-sodium - instructions for use, dose, side effects, contraindications

Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action is associated with competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of dihydrofolic acid and, ultimately, its active metabolite of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.

It is active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus antracis, Corynebacterium diphteriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics:With topical application of Cmax sulfanilamides in the cornea (about 3 mg / ml), the anterior chamber moisture (about 0.5 mg / ml) and iris (about 0.1 mg / ml) is achieved in the first 30 minutes after application. Some amount (less than 0.5 mg / ml) is stored in the tissues of the eyeball for 3-4 hours. If the epithelium of the cornea is damaged, the penetration of sulfonamides is enhanced.

Indications:Conjunctivitis, blepharitis, purulent corneal ulcer, prevention and treatment of blenarus in newborns, gonorrhea and chlamydia eye diseases in adults.

Contraindications:Individual hypersensitivity to the components of the drug.

Pregnancy and lactation:Sufficient experience in use during pregnancy, breast-feeding is not. It is possible to use sulfacetamide to treat pregnant and lactating mothers as prescribed by the doctor if the expected curative effect exceeds the risk of possible side effects. Sulfonilamides penetrate the placenta and into breast milk.

Dosing and Administration:Bury in a conjunctival bag for 1-2 drops 5-6 times a day. For the prevention of blennery in newborns - 2 drops in each conjunctival sac immediately after birth and 2 drops - after 2 hours.

Side effects:Burning, lacrimation, itching, itching in the eyes, allergic reactions.

Overdose:

Data on drug overdose are absent.

Interaction:The combined use with procaine and tetracaine reduces the bacteriostatic effect of sodium sulfacil. The incompatibility of sulfacyl sodium is observed when it is used together with silver salts. Simultaneous administration with chloramphenicol increases the risk of side effects of the latter.

Special instructions:

Patients who are hypersensitive to furosemide, thiazide diuretics,derivatives of sulfonylureas or inhibitors of carbonic anhydrase may have increased sensitivity to sulfacetamide.

Form release / dosage:

Eye drops 20%.

Packaging:

To 5, 10 ml in sterile polymer bottles-droppers, hermetically sealed by polymer stoppers, droppers and lids.

By 5, 10 ml in sterile polymer bottles-droppers, manufactured by technology

"blow-fill-seal" blow-fill-seal "on the production line of Bottelpack, hermetically sealed with screw caps.

For 1 polymer bottle-dropper along with the instruction for medical use is placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

The bottle-dropper should be used after opening for 30 days.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000174

Date of registration:17.01.2011

The owner of the registration certificate:SLAVYANSKAYA APTEKA, LLC SLAVYANSKAYA APTEKA, LLC Russia

Manufacturer: & nbsp

SLAVYANSKAYA APTEKA, LLC Russia

Information update date: & nbsp03.09.2015

Illustrated instructions

Instructions

Sulfacil sodium (Sulfacyl-sodium)