Sulfacil sodium - instructions for use, dose, side effects, contraindications

The mechanism of action is due to competitive antagonism with paraaminobenzoic acid and inhibition of dihydropteroate synthetase, a violation of the synthesis of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.

It is active against gram-positive and gram-negative cocci,

Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics:When topically applied, the maximum concentration (Cmax) of sulfonamides in the cornea (about 3 mg / ml), the anterior chamber humidity (about 0.5 mg / ml) and the iris (about 0.1 mg / ml) is achieved in the first 30 minutes after application. Some amount (less than 0.5 mg / ml) is stored in the tissues of the eyeball for 3-4 hours. If the epithelium of the cornea is damaged, the penetration of sulfonamides is enhanced.

Indications:As part of complex therapy. Conjunctivitis and blepharitis in children and adults, purulent corneal ulcer, prophylaxis and treatment of blenorei in newborns, gonorrhea and chlamydia eye diseases in adults.

Contraindications:Hypersensitivity to the components of the drug.

Pregnancy and lactation:Sufficient experience in the use of the drug during pregnancy, breast-feeding is not. It is possible to use sulfacetamide to treat pregnant and lactating mothers as prescribed by the doctor if the expected curative effect exceeds the risk of possible side effects.

Dosing and Administration:

Locally.

For the treatment of conjunctivitis in children and adults, they instill in the conjunctival sac every 1-2 hours, for the next 3-4 days - 5-6 times a day.

For the treatment of blepharitis in children and adults, the frequency of installations for the first time days is up to 6-8 times and decreases to 3-4 times a day as the condition improves, the duration of treatment is 3-5 days.

For treatment of purulent corneal ulcer as part of complex therapy in the form of installations 5-6 times a day for 5-7 days.

For the prevention of blennery in newborns, 2 drops in each conjunctival sac immediately after birth and 2 drops, 2 hours during the day, to treat blenorrhea - in each conjunctival sac 2 drops every 1 -2 hours for the first time, then every 3 hours, the duration of treatment is two weeks.

In the treatment of gonorrheal and chlamydial eye diseases in adults in complex therapy, 1-2 drops 5-6 times a day for 4-6 weeks.With positive dynamics against the background of ongoing treatment, the number of drops installations is reduced in each subsequent week.

Side effects:Burning, lacrimation, stinging, itching in the eyes, transient fogging of vision after instillation, allergic reactions.

Overdose:Data on drug overdose are absent.

Interaction:The combined use with procaine and tetracaine reduces the bacteriostatic effect. Incompatibility with silver salts.

Special instructions:Patients who are hypersensitive to furosemide, thiazide diuretics, sulfonyl urea or inhibitors of carbonic anhydrase may have increased sensitivity to sulfacetamide. After opening, use within 14 days.

Effect on the ability to drive transp. cf. and fur:If the patient after application of the drug temporarily reduces the clarity of visual perception, it is not recommended to drive the car and engage in forks that require attention and reaction before it is restored.

Form release / dosage:Eye drops 20%.

Packaging:

1 ml, 1.5 ml, 2 ml in a dropper with a valve or 5 ml, 10 ml in a tube with a screw mouth from polymeric materials.

Tube-dropper with a screw neck is capped with screw caps made of polymer materials.

2 Tube-dropper on 1 ml, 1.5 mm, 2 ml or 1 tube-dropper on 5 ml, 10 ml with the instruction on application place in a pack from a cardboard.

Storage conditions:In the dark place at a temperature of no higher than 2 to 15 ° C. Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-001909

Date of registration:24.08.2011

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Information update date: & nbsp03.09.2015

Illustrated instructions

Instructions

Sulfacil sodium (Sulfacyl-sodium)