Angiovitis - instructions for use, dose, side effects, contraindications

auxiliary substances for the preparation of a core tablet weighing 0.20 g: sucrose (granulated sugar) 118.761 mg, potato starch 47.528 mg, croscarmellose sodium (impellose) 18,705 mg, talc 4,000 mg, calcium stearate 2,000 mg;

auxiliary substances for obtaining a shell with a mass of 0.14 g: sucrose (sugar) 72,477 mg, wheat flour 30,637 mg, magnesium hydroxycarbonate pentahydrate 29,140 mg, titanium dioxide 6,655 mg, methyl cellulose 0.405 mg, gelatin 0.306 mg, sunflower oil 0.162 mg, beeswax 0.143 mg, talc 0.075 mg.

Weight of tablet: 0.340 g.

Description:Round, biconvex tablets are white, coated. Two layers are visible on the cross-section.

Pharmacotherapeutic group:Multivitamins

ATX: & nbsp

A.11.B.A Multivitamins

Pharmacodynamics:

The pharmacological properties of the drug Angiovit® are due to the action of the vitamins of group B, included in its composition.

Folic acid - involved in the synthesis of amino acids, DNA and RNA, stimulates erythropoiesis. Folic acid reduces the risk of spontaneous abortion in the early stages of pregnancy, and also prevents the occurrence of congenital intrauterine malformations of the cardiovascular and nervous systems of the fetus, and the developmental limbs associated with a deficiency in folic acid intake during fetal development.

Vitamin B₁₂ (cyanocobalamin) - involved in many metabolic processes, is necessary for the synthesis of DNA. Cyanocobalamin participates in the formation of myelin, a component of the sheath of nerve fibers; with a deficiency of cyanocobalamin during pregnancy in the fetus, the process of forming the myelin sheath of the nerves may be slowed down. Increases the resistance of erythrocytes to hemolysis. Increases the ability of tissues to regenerate.

Vitamin B₆ (pyridoxine) - is involved in the metabolism; is necessary for the normal functioning of the central and peripheral nervous system. Prevents the development of nausea and vomiting, with toxicosis of pregnant women. Replenishes the deficiency of pyridoxine, which can occur in the case of taking oral contraceptives before pregnancy.

Vitamins of group B (folic acid, AT₆ and B₁₂) play an important role in the metabolism of homocysteine. Angiovit® has the ability to activate the key enzymes in the body and transsulfuratsii remethylation methionine - methylenetetrahydrofolate and tsistation-B-synthetase, thereby accelerating the exchange of methionine and a reduction in the blood homocysteine kontsetratsii. Homocysteine is a predictor of pathological changes in the human body (cardiovascular diseases, pathologies of pregnancy, neuropsychic disorders).Against the background of complex application of these vitamins, homocysteine levels in the blood are normalized.

Pharmacokinetics:

Folic acid is rapidly absorbed in the small intestine, undergoing a reduction and methylation to 5-methyltetrahydrofolate, which is present in the portal circulation. The maximum concentration in plasma is observed 30-60 minutes after administration. Vitamin B₁₂ is absorbed after to its interaction in the stomach with the "internal factor of Castle", a glycoprotein that is secreted by parietal cells of the stomach. The maximum concentration in plasma is observed after 8-12 hours. As with folic acid, vitamin B₁₂ is subject to significant intestinal hepatic recirculation.

Both components largely bind to plasma proteins, excess accumulates in the liver.

Every day, 4-5 μg of folate is excreted in the urine in the form of folic acid, 10-formyltetrahydrofolate and 5-methyltetrahydrofolate. Folate is also excreted in breast milk. Average half-life of vitamin B₁₂ is about 6 days. Part of the administered dose is excreted in the urine for the first 8 hours, most of it is excreted with bile.On average, 25% of metabolites are excreted with feces.

Vitamin B₁₂penetrates the placenta and is present in breast milk.

Vitamin B₆ easily absorbed in the gastrointestinal tract and converted in the liver in pyridoxalphosphate (the active form of this vitamin). In the blood, non-enzymatic conversion of pyridoxine to pyridoxamine occurs, after which part of the final product of metabolism - 4-pyridoxyl acid is formed. In the tissues pyridoxine is converted by phosphorylation to pyridoxine phosphate, pyridoxalphosphate and pyridoxamine phosphate. The product of the conversion of pyridoxal is 4-pyridoxyl and 5-phosphopyridoxyl acids. Both these products are excreted by the urine of the kidneys.

Indications:Prevention of deficiency of vitamins included in the preparation; hyperhomocysteinemia.

Contraindications:

Hypersensitivity to components drug, child age, the period of breastfeeding, a deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption.

Pregnancy and lactation:

During pregnancy, the drug is used for indications to prevent fetal development of congenital malformations with hyperhomocysteinemia,with a history of neural tube defects.

Folic acid penetrates into breast milk. During the period of breastfeeding, the use of the drug is not recommended.

Dosing and Administration:

Inside, 1 tablet a day, regardless of food intake.

The course of treatment is 20-30 days. If necessary, the course of treatment is repeated appointment of a doctor.

Side effects:

Allergic reactions.

Overdose:

Increased symptoms of adverse drug effects, nausea, dizziness.

The first aid consists in washing the gastrointestinal tract, reception of activated charcoal, symptomatic therapy.

Interaction:

Folic acid

Reduces the effect of phenytoin (requires an increase in its dose).

Analgesics (long-term therapy), anticonvulsant drugs (incl. phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including preparations of aluminum and magnesium), colestramine, sulfonamines (incl. sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid.

Pyridoxine hydrochloride

Strengthens the action of diuretics; weakens the activity of levodopa.

Isonicotin hydrazide, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine.

It is well combined with cardiac glycosides (pyridoxine promotes an increase in the synthesis of contractile proteins in the myocardium), with glutamic acid and asparcam (increases resistance to hypoxia).

Cyanocobalamin

Aminoglycosides, salicylates, antiepileptic drugs, colchicine, potassium preparations reduce the absorption of cyanocobalamin.

Increases the risk of allergic reactions against thiamine.

You can not combine with drugs that increase blood coagulability.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles or work with dangerous mechanisms.

Form release / dosage:

The tablets covered with a cover.

Packaging:

For 10 tablets in contour mesh packaging.

6 contour mesh packages together with instructions for use are placed in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N003699 / 01

Date of registration:25.08.2009 / 22.12.2016

Expiration Date:Unlimited

The owner of the registration certificate:ALTAYVITAMINS, CJSC ALTAYVITAMINS, CJSC Russia

Manufacturer: & nbsp

ALTAYVITAMINS, CJSC Russia

Representation: & nbspALTAYVITAMINS, CJSCALTAYVITAMINS, CJSC

Information update date: & nbsp04.09.2017

Illustrated instructions

Instructions

Angiovit® (Angiovit®)