Intravenously.
Adults appoint 750 mg three times a day; with infections of severe course - the dose is increased to 1500 mg 3-4 times a day (if necessary, the interval between administrations can be reduced to 6 hours). The average daily dose is 3-6 g.
Children older than 3 months appoint 30-100 mg / kg / day 3-4 times a day. In most infections, the optimal dose is 60 mg / kg / day.
Children up to 3 months old appoint 30 mg / kg / day 2-3 times a day.
With bacterial meningitis - adults - 3 g every 8 hours; children younger and older - 150-250 mg / kg / day 3-4 times a day, the newborn - 100 mg / kg / day 2-3 times a day.
At operations on heart, lungs, an esophagus, vessels, an abdominal cavity, organs of a small basin and at orthopedic operations - 1500 mg with the induction of anesthesia.When the joint is fully replaced, 1500 mg of the powder is dry mixed with each polymer methyl methacrylate cement pack before adding the liquid monomer.
With pneumonia appoint 1500 mg 2-3 times a day.
With an exacerbation of chronic bronchitis appoint 750 mg 2-3 times a day.
In chronic renal failure correction of the dosing regimen is necessary; when creatinine is cleared, 10-20 ml / min is prescribed 750 mg twice a day, with creatinine clearance less than 10 ml / min 750 mg once a day.
Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily; for patients on low-speed haemofiltration, doses recommended for renal impairment are prescribed.
Preparation of solution for injection:
Solution for intravenous bolus administration: Dissolve 1.5 g of the drug in 15 ml of water for injection.
Solution for intravenous infusion introduction:
For intravenous infusions, 1.5 g of the drug is dissolved in 15 ml of water for injection, the resulting solution is added to 50-100 ml of a compatible infusion solution.
When mixing a solution of cefuroxime (1.5 g in 15 ml of water for injection) and metronidazole (50 mg / 100 ml), both components remain active for up to 24 hours at 4 ° C or 6 hours at a temperature below 25 ° C.
Cefuroxime is compatible with the most commonly used liquid for intravenous administration:
- 0.9% solution of sodium chloride;
- 5% solution of dextrose;
- Ringer's solution;
- Hartmann solution.
Cefuroxime is compatible with solutions:
- heparin (10 U / ml and 50 U / ml) in a 0.9% solution of sodium chloride;
- Potassium chloride (10 mEq / L and 40 mEq / L) in a 0.9% solution of sodium chloride. Cefuroxime remains stable in a 0.9% solution of sodium chloride and in a 5% solution of dextrose in the presence of hydrocortisone sodium phosphate.