In / m, in / in.
In / in and / m adults are prescribed 750 mg every 8 hours; with infections of severe course - the dose is increased to 1500 mg every 6-8 hours. The average daily dose is 3-6 g. The average course of treatment is 5-10 days.
With gonorrhea - in / m 1500 mg once (or in the form of 2 injections of 750 mg with the introduction of different
region, for example, in both gluteal muscles).
With bacterial meningitis - IV, 3 g every 8 hours.
With infection of bones and joints-1500 mg every 8 hours.
In surgeries on the abdominal cavity, pelvic organs and orthopedic operations - 1500 mg with the induction of anesthesia, then additionally - in / m 750 mg, 8 and 16 hours after the operation. At operations on heart, lungs, an esophagus and vessels - in / in 1500 mg at an induction of anesthesia, then - in / m on 750 mg 3 times a day during the subsequent 24-48 hours.
When pneumonia - in / m or / in the 1500 mg 2-3 times a day for 48-72 hours, then go to the inside, 500 mg 2 times a day for 7-10 days.
With an exacerbation of chronic bronchitis, I / m or IV is prescribed 750 mg 2-3 times a day for 48-72 hours, then go to the inside, 500 mg twice a day for 5-10 days. In chronic renal failure, correction of the dosing regimen is necessary: with QC more than 20 ml / min - appoint IV or IV 750-1500 mg every 8 hours, 10-20 ml / min given IV or IV 750 mg every 12 hours, with a CC less than 10 ml / min, 750 mg every 24 hours. Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily at the end of the session hemodialysis; for patients on low-velocity haemofiltration, doses recommended for renal impairment are prescribed.Children are prescribed 30-100 mg / kg / day in 3-4 divided doses. In most infections, the optimal dose is 60 mg / kg / day. In severe and life-threatening infections, doses of 100 mg / kg / day (but not exceeding the dose in adults) can be used. In the case of bacterial meningitis, high doses of 200-240 mg / kg / day IV are used, divided into equal doses, which are administered every 6-8 hours.
With infection of bones and joints - 150 mg / kg / day, divided into equal doses, which are administered every 8 hours.
If the renal function is impaired, the frequency of administration should correspond to the frequency of application of the drug in adults with concomitant renal failure. Newborns and children under 3 months are prescribed 30 mg / kg / day in 2-3 sessions; at bacterial meningitis - 100 mg / kg / day.
Rules for the preparation of a solution for intravenous administration
750 mg of the preparation is dissolved in 8.0 ml of water for injection to obtain a solution with a concentration of about 90 mg / ml. Enter slowly for 3-5 minutes.
For short-term infusion (up to 30 min), 1500 mg of the drug are dissolved in 50 ml of water for injection, or in one of the compatible solvents: 5% dextrose (glucose) solution, 0.9% sodium chloride solution. The resulting solutions are injected directly into the vein or into the tube of the infusion system.
For continuous infusion, the drug solution is diluted with one of the following solutions: water for injection, 5% dextrose (glucose) injection, 10% dextrose (glucose) injection, 0.9% sodium chloride solution, 5% dextrose (glucose) solution and 0.9% sodium chloride injection, 5 % solution of dextrose (glucose) and 0.45% solution of sodium chloride for injection, sodium lactate solution for injection.
Rules for the preparation of a solution for the / m introduction
750 mg of the drug is diluted in 3 ml of water for injection, gently shaken until a solution is obtained. The prepared solution is injected deep into the large gluteus muscle or into the anterior surface of the thigh