The drug is used in / m and / in.
Adults: in / in and in / m 750 mg-1.5 g every 8 h. In severe or complicated infections - in / in 1.5 g every 8 h.If necessary, the interval between administrations may be reduced to 6 hours and the daily dose can be from 3 to 6 g. The course of treatment is usually from 5 to 10 days.
For children: appoint iv 30-100 mg / kg / day every 6-8 hours. In the treatment of most infections, the optimal daily dose is 60 mg / kg.
Newborns: appoint iv in a dose of 30-100 mg / kg / day, divided into 2-3 doses (in the first weeks of life, the half-life of cefuroxime in the blood serum of a newborn can be 3-5 times higher than that of an adult).
With pneumonia - appoint 1.5 g IV or IM 2-3 times a day for 48-72 hours, and then go to the reception inside (use dosage forms for intravenous administration) of 500 mg twice a day for 7 -10 days. The duration of each period (parenteral therapy and oral administration) is determined by the severity of the infection and the general condition of the patient.
With an exacerbation of chronic bronchitis - appoint IV or IV 750 mg 2-3 times a day for 48-72 hours, then go to the inside (use medicinal forms for oral administration) 500 mg 2 times a day for 5-10 days. The duration of each period (parenteral therapy and oral administration) is determined by the severity of the infection and the general condition of the patient.
With bacterial meningitis - adults are assigned IV, 3.0 g every 8 hours; children younger and older - in / in 150-250 mg / kg / day in 3-4 reception. After 3 days in case of clinical improvement, the dose can be reduced to 100 mg / kg / day. The newborn drug is given IV / IV at a dose of 100 mg / kg / day.
With gonorrhea - 1,5 g in the form of IM injection once (as 2 injections of 750 mg with the introduction into different areas, for example, in both gluteal muscles).
For the prevention of surgical interventions:
- at operations on an abdominal cavity, bodies of a basin and at orthopedic operations - in / in, 1,5 g at an anesthesia induction, then in addition - in / m 750 mg, through 8 h and 16 h after operation;
- at operations on heart, lungs, an esophagus, vessels and orthopedic operations - in / in, 1,5 g at an anesthesia induction, then - in / m, on 750 mg 3 times a day during the next 24-48 hours;
- when the joint is fully replaced, 1.5 g of the powder is mixed in dry form with each polymer methyl methacrylate cement pack before adding the liquid monomer.
In chronic renal failure, correction of the dosing regimen is necessary:
- with the clearance of creatinine 10-20 ml / min is administered IV or IV 750 mg 2 times a day,
- when creatinine clearance is less than 10 ml / min - 750 mg once a day.
Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily. Patients on low-velocity haemofiltration are given doses recommended for renal dysfunction. Patients on hemodialysis at the end of each hemodialysis session should be administered an additional dose of 750 mg.
Preparation of solutions for administration:
The solutions are prepared in aseptic conditions.
For intramuscular injection - in a bottle containing 750 mg, add 3 ml of water for injection and mix thoroughly.
For intravenous administration - in a vial containing 750 mg, add 6 ml of water for injection and mix thoroughly.
For intravenous infusion - 1.5 g of the drug is dissolved in 50 ml of water for injection and mixed thoroughly.