In / in and / m adults are prescribed 750 mg 3 times a day; for infections of severe course, the dose is increased to 1500 mg 3-4 times a day (if necessary, the interval between administrations can be reduced to 6 hours). The average daily dose is 3-6 g. Children are prescribed 30-100 mg / kg / day in 3-4 divided doses. In most infections, the optimal dose is 60 mg / kg / day. Newborns and children under 3 months are prescribed 30 mg / kg / day in 2-3 doses.
With gonorrhea - in / m, 1500 mg (in the form of 2 injections of 750 mg with the introduction into different areas, for example, in both gluteal muscles).
With bacterial meningitis - IV, 3 g every 8 hours; children younger and older - 150-250 mg / kg / day in 3-4 doses, newborns -100 mg / kg / day. In operations on the abdominal cavity, pelvic organs and in orthopedic operations - IV, 1500 mg with the induction of anesthesia, then additionally - in / m, 750 mg, 8 and 16 hours after the operation.When the joint is completely replaced, 1500 mg of the powder is mixed dry with each polymer-methacrylate cement polymer packet before adding the liquid monomer.
At operations on heart, lungs, an esophagus and vessels - in / in, 1500 mg at an induction of anesthesia, then - in / m, on 750 mg 3 times day for the next 24-48 hours. At a pneumonia - in / in, on 1500 mg 2-3 times a day for 48-72 hours, then switch to oral administration, 500 mg twice a day for 7-10 days.
When exacerbation of chronic bronchitis is prescribed in / m or / in, 750 mg 2-3 times a day for 48-72 hours, then switch to oral administration, 500 mg twice a day for 5-10 days.
When CRF requires correction mode: the creatinine clearance (CC) of 10-20 ml / min administered in / in or / m to 750 mg 2 times a day, with CC than 10 ml / min - 750 mg 1 time per day .
Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily; for patients on low-velocity haemofiltration, doses recommended for renal impairment are prescribed.
Preparation of solution for injection:
for IM injections:
Add 3 ml of water for injection to 750 mg of cefuroxime. Gently shake until a slurry forms.With the / m introduction cefuroxime is compatible with aqueous solutions containing up to 1% lidocaine hydrochloride. Cefuroxime in a dose of 1500 mg is only for IV administration.
Solution for intravenous administration
Dissolve
- 750 mg cefuroxime in 6 ml or more water for injection, -1.5 g cefuroxime in 15 ml or more water for injection.
For short-term intravenous infusions (up to 30 min), 1.5 g of the drug is dissolved in 50 ml of water for injection. These solutions can be injected directly into the vein or into the tube of the infusion system.
When mixing a solution of cefuroxime (1.5 g in 15 ml of water for injection) and metronidazole (50 mg / 100 ml), both components remain active for up to 24 hours at a temperature of 4 ° C or up to 6 hours at a temperature below 25 ° C FROM.
Cefuroxime is compatible with the most commonly used liquid for intravenous administration. The preparation is stable up to 24 hours at room temperature when mixed with the following solutions:
- 0.9% solution of sodium chloride; -5% solution of dextrose;
- Ringer's solution;
- Hartman solution.
Cefuroxime remains stable in a 0.9% solution of sodium chloride and in a 5% solution of dextrose in the presence of hydrocortisone sodium phosphate.
With the following solutions cefuroxime compatible for 24 hours at room temperature:
- heparin (10 U / ml and 50 U / ml) in a 0.9% solution of sodium chloride;
- potassium chloride (10 mEq / L and 40 mEq / L) in a 0.9% solution of sodium chloride. Cefuroxime Do not mix in one syringe with antibiotics from the aminoglycoside group.
A solution of sodium hydrogencarbonate 2.74% has a pH that significantly affects the color of the solution of cefuroxime, so it is not recommended to use it for dilution. If necessary, the solution of sodium hydrogen carbonate can be injected directly into the tube of the infusion system.