In / in and / m adults are prescribed 750 mg 3 times a day; with infections of severe course - the dose is increased to 1500 mg 3-4 times a day (if necessary, the interval between administrations can be reduced to 6 hours). The average daily dose is 3-6 g.
With gonorrhea - in / m, 1500 mg, once (or as 2 injections of 750 mg with introduction into different areas, for example, in both gluteal muscles).
With bacterial meningitis - IV, 3 g every 8 hours; children younger and older - 150-250 mg / kg / day in 3-4 doses, newborns - 100 mg / kg / day. In surgeries on the abdominal cavity, pelvic organs and in orthopedic operations - IV, 1500 mg with the induction of anesthesia, then additionally - in / m, 750 mg, 8 and 16 hours after the operation.
At operations on heart, lungs, an esophagus and vessels - in / in, 1500 mg at an induction of anesthesia, then - in / m, on 750 mg 3 times a day during the subsequent 24-48 ch.
When the joint is completely replaced, 1500 mg of the powder is mixed dry with each polymer-methacrylate cement polymer packet before adding the liquid monomer. When pneumonia - in / m or / in, 1,500 mg 2-3 times a day for 48-72 h, then go to the inside, 500 mg 2 times a day for 7-10 days.
When exacerbation of chronic bronchitis is prescribed in / m or / in, 750 mg 2-3 times a day for 48-72 hours, then switch to oral administration, 500 mg twice a day for 5-10 days. Children are prescribed 30-100 mg / kg / day in 3-4 divided doses. In most infections, the optimal dose is 60 mg / kg / day. Newborns and children up to 3 months. appoint 30 mg / kg / day in 2-3 hours.
In chronic renal failure (CRF), correction of the dosing regimen is necessary: with a CC of 10-20 ml / min, IV or IV is given 750 mg twice a day, with a CC less than 10 ml / min 750 mg once a day day.
Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily; for patients on low-velocity haemofiltration, doses recommended for renal impairment are prescribed.
Preparation of solution for injection:
Solution for the / m introduction:
Add 1 ml of water for injection to 250 mg of cefuroxime. Add 3 ml of water for injection to 750 mg of cefuroxime. Gently shake until a slurry forms.
Solution for intravenous administration: Dissolve:
- 250 mg of cefuroxime in 2 ml of water for injection,
- 750 mg of cefuroxime in 6 ml of water for injection,
For short-term intravenous infusions (up to 30 min), 750 mg of the drug is dissolved in 25 ml of water for injection. These solutions can be injected directly into the vein or into the tube of the infusion system.
When mixing a solution of cefuroxime (750 mg in 6 ml of water for injection) and metronidazole (25 mg / 50 ml), both components remain active for up to 24 hours at a temperature of 4 ° C or up to 6 hours at a temperature below 25 ° C.
A solution of cefuroxime (5 mg / ml) in 5% or 10% xylitol solution can be stored for up to 24 hours at a temperature below 25 ° C.
Cefuroxime is compatible with aqueous solutions containing up to 1% lidocaine hydrochloride. Cefuroxime compatible with the most widely used liquid for intravenous administration. The preparation is stable up to 24 h at room temperature when mixed with the following solutions:
- 0.9% solution of sodium chloride;
- 5% dextrose solution;
- Ringer's solution;
- Hartman solution.
Axoxef® remains stable in a 0.9% solution of sodium chloride and in a 5% solution of dextrose in the presence of hydrocortisone sodium phosphate.
With the following solutions, Axoxef is compatible for 24 hours at room temperature:
- heparin (10 U / ml and 50 U / ml) in a 0.9% solution of sodium chloride;
- potassium chloride (10 mEq / L and 40 mEq / L) in a 0.9% solution of sodium chloride.
Axoxef® should not be mixed in the same syringe with antibiotics from the aminoglycoside group. A solution of sodium bicarbonate 2.74% has a pH value that significantly affects the color of the solution of Cefuroxime, so it is not recommended to use it for dilution. However, if a sodium bicarbonate solution is administered to the patient, then, if necessary, it can be injected directly into the tube of the infusion system.