The following side effects are classified by organs and systems and by frequency-appearance: very often (>1/10); often (>1/100 and <1/10); infrequently (>1/1000 and <1/100); rarely - (>1/10 000 and <1/1000); very rarely (<1/10 000).
Other: often excessive growth Candida after long-term use.
On the part of the blood and lymphatic system
Often - eosinophilia.
Infrequently - false positive Coombs test, thrombocytopenia, leukopenia.
Very rarely - hemolytic anemia.
Allergic reactions
Hypersensitivity reactions, including: infrequently - skin rash; rarely - hives, itching; very rarely - drug fever, serum sickness, bronchospasm, anaphylactic shock, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
From the nervous system
Often - a headache, dizziness.
From the digestive system
Often - gastroenterological disorders, including diarrhea, nausea, abdominal pain.
Infrequent - vomiting.
Rarely, pseudomembranous colitis.
From the hepatobiliary system
Often - a transient increase in the activity of "hepatic" enzymes: alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (ALT, ASAT, LDH).
Very rarely - jaundice (mostly cholestatic), hepatitis.
From the sense organs
Rarely, hearing loss.
From the genitourinary system
Rarely, itching in the perineum, vaginitis.