The drug is used intramuscularly and intravenously.
Adults: usually appointed cefuroxime in a dose of 750 mg-1.5 g every 8 hours. The course of treatment is usually from 5 to 10 days.
Newborns - appoint IV in a dose of 30-100 mg / kg / day, divided into 2-3 doses (in the first weeks of life, the half-life of cefuroxime in the blood serum of a newborn can be 3-5 times higher than in an adult).
Infants and children under 12 years - appoint iv 30-100 mg / kg / day every 6-8 hours. In the treatment of most infections, the optimal daily dose is 60 mg / kg.
With pneumonia - appoint 1.5 g IV or IM 2-3 times a day for 48-72 hours, and then go to the inside (use medicinal forms for oral administration) of 500 mg 2 times a day for 7 -10 days.
With an exacerbation of chronic bronchitis - appoint IV or IV 750 mg 2-3 times a day for 48-72 hours, then go to the inside (use medicinal forms for oral administration) 500 mg 2 times a day for 5-10 days.
With uncomplicated urinary tract infection, skin infection, disseminated gonococcal infection, and uncomplicated pneumonia - appoint 750 mg every 8 hours. If necessary, the interval between administrations can be reduced to 6 hours and the daily dose will rise to 3-6 g. In severe or complicated infections, 1.5 g every 8 hours is prescribed.
With bacterial meningitis - appoint IV, 3.0 g every 8 hours; children younger and older - in / in 150-250 mg / kg / day in 3-4 reception.After 3 days in case of clinical improvement, the dose can be reduced to 100 mg / kg / day. The newborn drug is administered IV in a dose of 100 mg / kg / day.
With gonorrhea - 1,5 g in the form of IM injection once (as 2 injections of 750 mg with the introduction into different areas, for example, in both gluteal muscles).
For the prevention of surgical interventions:
- at operations on an abdominal cavity, bodies of a basin and at orthopedic operations - in / in, 1,5 g at an anesthesia induction, then in addition - in / m 750 mg, through 8 h and 16 h after operation;
- at operations on heart, lungs, an esophagus, vessels and orthopedic operations - in / in, 1,5 g at an anesthesia induction, then - in / m, on 750 mg 3 times a day during the next 24-48 hours;
- when the joint is fully replaced, 1.5 g of the preparation is dry mixed with each polymer methyl methacrylate cement pack before adding the liquid monomer.
In chronic renal failure correction of the dosing regimen is necessary:
- with a creatinine clearance of 10-20 ml / min is given either IV or IV 750 mg twice daily,
- when creatinine clearance is less than 10 ml / min - 750 mg once a day.
Patients on continuous hemodialysis using an arteriovenous shunt or high-speed haemofiltration in intensive care units are prescribed 750 mg twice daily.Patients on low-velocity haemofiltration are given doses recommended for renal dysfunction.
Preparation of solutions for administration:
The solutions are prepared in aseptic conditions.
For intramuscular injection - in a bottle containing 1.5 g of the drug, add 6 ml of water for injection and mix thoroughly.
For intravenous administration - in a bottle containing 1.5 g, add 15 ml of water for injection and mix thoroughly.
For short-term intravenous infusions (no more than 30 min): 1.5 g of cefuroxime is dissolved in 50-100 ml of water for injection. These solutions are injected directly into the veins or indirectly, using a system for infusion solutions.
For slow intravenous administration additionally dissolved in 50 ml of 5% or 10% solution of dextrose for injection, 0.9% solution of sodium chloride for injection, Ringer's solution, Ringer's solution with lactate.
In accordance with the requirements of good clinical practice, it is recommended to use only freshly prepared solutions, but the solution remains stable for 24 hours when stored in a refrigerator (2-8 ° C).