Intramuscularly, intravenously.
Intravenous and intramuscular adults appoint 0.75 g 3 times a day; with infections of severe course - the dose is increased to 1.5 g 3-4 times a day (if necessary, the interval betweenintroductions can be reduced to 6 hours). The average daily dose is 3-6 g.
Children older than 3 months appoint 30-100 mg / kg / day in 3-4 injections. In most infections, the optimal dose is 60 mg / kg / day.
Newborns and children under 3 months appoint 30 mg / kg / day in 2-3 introduction.
With gonorrhea - intramuscularly, adult 1.5 g once (in the form of 2 injections of 0.75 grams per second introduction into different areas, for example, in both gluteal muscles).
With bacterial meningitis - intravenously, adults - 3 g every 8 hours; children younger and older - 150-250 mg / kg / day in 3-4 injections, newborns -100 mg / kg / day in 2-3 injections.
For the prevention of postoperative complications:
- at operations on heart, lungs, an esophagus and vessels - intravenously, 1.5 g for 0,5 - 1 hour before operation and on 0.7 g intravenously or intramuscularly every 8 hours at prolonged operations for the next 24 to 48 hours (for open heart operations, the total dose to 6 g);
- with operations on the abdominal cavity, pelvic organs and orthopedic operations -
intravenously, 1.5 g with induction of anesthesia, then additionally - intramuscularly, 0.75 g, 8 and 16 hours after the operation;
-if a complete replacement of the joint - 1.5 g of the powder are mixed in dry form with each polymer methyl methacrylate cement packet before adding the liquid monomer.
With pneumonia - intramuscularly or intravenously, 1.5 g 2-3 times a day for 48-72 hours, then switch to oral administration (use medicinal forms for ingestion) 0.5 g 2 times a day for 7-10 days.
With an exacerbation of chronic bronchitis administered intramuscularly or intravenously, by 0.75 g 2-3 times a day for 48-72 h, then switch to ingestion (use dosage forms for oral administration) 0.5 g 2 times a day for 5-10 days.
In chronic renal failure correction of the dosing regimen is necessary in adults: with the clearance of creatinine (CC) 10-20 ml / min administered intravenously or intramuscularly by 0.75 g 2 times a day, with a CC less than 10 ml / min - 0.75 g once a day.
In chronic renal failure in children, the dosing regimen should be changed in accordance with the recommendations for adults.
Patients on continuous hemodialysis using arteriovenousshunt or high-velocity haemofiltration in intensive care units, appoint 0.75 g 2 times a day; for patients on hemofiltration low speed, prescribe doses, recommended for violation of kidney function.
Preparation of suspension for intramuscular administration:
0.75 g (10 ml vial) is dissolved in 3 ml of water for injection.
1.5 g (20 ml vial) is dissolved in 6 ml of water for injection.
Gently shake until a slurry forms.
Preparation of a solution for intravenous administration:
0.75 g (10 ml vial) is dissolved in 9 ml of water for injection.
1.5 g (20 ml vial) dissolve in 14 ml of water for injection.
Solution for intravenous infusion.
In the case of short-term intravenous infusions (eg, up to 30 min), 1.5 g is dissolved in 50 ml of water for injection. These solutions can be injected directly into a vein or dropper if the patient is given parenteral fluid.