Arthraldol - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Chondroitin sulfate - the main component of proteoglycans, which together with collagen fibers are a cartilage matrix. Has chondroprotective properties; inhibits the activity of enzymes that cause degradation of the articular cartilage; stimulates the production of proteoglycans by chondrocytes; strengthens metabolic processes in cartilage and subchondral bone; affects the phosphoric-calcium metabolism in the cartilaginous tissue, stimulates its regeneration, participates in the construction of the basic substance of bone and cartilaginous tissue.It has anti-inflammatory and analgesic properties, helps to reduce the release of inflammatory mediators and pain factors into the synovial fluid through synovial and macrophage synovial membranes, suppresses the secretion of leukotriene B4 and prostaglandin E2. The drug contributes to the restoration of the cartilaginous surfaces of the joints, prevents the collapse of connective tissue; normalizes the production of articular fluid, which leads to better mobility of joints, reducing pain intensity. Having a structural similarity with heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondral microcirculatory bed.

Pharmacokinetics:Chondroitin sulfate is easily absorbed when administered intramuscularly, after 30 minutes it is found in significant concentrations in the blood, after 15 minutes - in the synovial fluid. The maximum concentration is achieved 1 h after the administration, then the concentration of the drug slowly decreases within 2 days. The drug accumulates mainly in the cartilaginous tissue (the maximum concentration in the articular cartilage is reached after 48 hours). It is excreted by the kidneys within 24 hours.

Indications:Degenerative and dystrophic diseases of the joints and spine: primary arthrosis, osteoarthrosis with predominant lesion of large joints, intervertebral osteochondrosis.

Contraindications:Hypersensitivity, children's age (efficacy and safety not established).

Carefully:Bleeding and a tendency to bleeding, thrombophlebitis. Pregnancy, lactation.

Dosing and Administration:Intramuscularly, 100 mg every other day. Before use, the contents of the ampoule are dissolved in 1 ml of water for injection. With good tolerability, the dose is increased to 200 mg, starting with the 4th injection. The course of treatment is 25-35 injections. Repeated course - after 6 months. The duration of repeated courses of treatment is set by the doctor.

Side effects:Allergic reactions, hemorrhages at the injection site.

Interaction:It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of coagulation rates when combined.

Form release / dosage:

Lyophilizate for the preparation of solution for intramuscular injection 100 mg.

Packaging:

Lyophilizate for the preparation of solution for intramuscular injection.100 mg in an ampoule with a capacity of 2 ml.

For 10 ampoules in a cardboard holder or 5 ampoules in a plastic tray.

1 cardboard holder or 2 plastic pallet, together with the instruction for use and the ampoule or scarifier ampoule in a cardboard bundle with a knife. When packing ampoules that have a break ring or a point for dissection, the ampoule knife or scarifier does not insert.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-009923/08

Date of registration:11.12.2008 / 25.12.2015

Expiration Date:Unlimited

The owner of the registration certificate:Inkamfarm, OOOInkamfarm, OOO Russia

Manufacturer: & nbsp

Kursk Biofactory - BIOK, FKP Russia

Armavir Biofactory, FKP

Information update date: & nbsp13.09.2017

Illustrated instructions

Instructions

Arthradol® (Artradol®)