Chondrolon - instructions for use, dose, side effects, contraindications

Chondroitin sulfate is the main component of proteoglycans that make up the cartilaginous matrix together with collagen fibers. Has chondroprotective properties; inhibits the activity of enzymes that cause degradation of the articular cartilage; stimulates the production of proteoglycans by chondrocytes; strengthens metabolic processes in cartilage and subchondral bone; participates in the construction of the main substance of bone and cartilaginous tissue. Has anti-inflammatory and analgesic effect, helps to reduce the release of synovial fluid mediators of inflammation and pain throughsynoviocytes and macrophages of the synovium, inhibits the secretion of leukotriene B4 and prostaglandin E2.

The drug contributes to the restoration of the cartilaginous surfaces of the joints, prevents the collapse of connective tissue; normalizes the production of the joint

Pharmacokinetics:

Chondrolon is easily absorbed when administered intramuscularly. The maximum concentration is achieved 1 hour after the administration. The drug accumulates in the synovial fluid. It is excreted from the body mainly by the kidneys within 24 hours.

Indications:Osteoarthritis of peripheral joints and spine.

Contraindications:Hypersensitivity to chondroitin sulfate, a tendency to bleeding, thrombophlebitis, pregnancy, the period of breastfeeding (at the time of treatment, breast-feeding should be discontinued).

Dosing and Administration:

Enter intramuscularly for 100 mg (1 ampoule) every other day. Before use, the contents of the ampoule are dissolved in 1 ml of water for injection. With good tolerability, the dose is increased to 200 mg (2 ampoules), starting with the fourth injection. The course of treatment is 25-35 injections. Repeated courses - after 6 months.

The duration of repeated courses of treatment is set by the doctor.To achieve a stable clinical effect, at least 25 injections of chondrolon are necessary, with the effect remaining long after the end of the second course of treatment.

The experience of the drug in children is not.

Side effects:Allergic reactions, hemorrhages at the injection site.

Interaction:Chondrolon may increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytic agents, which requires more frequent monitoring of blood coagulation indicators when combined with the use of drugs.

Form release / dosage:

Lyophilizate for the preparation of a solution for intramuscular injection of 100 mg.

Packaging:

Lyophilizate for the preparation of a solution for intramuscular injection of 100 mg in ampoules.

For 10 ampoules with instructions for use, with an ampoule or ampoule ampoule knife in a pack or box of cardboard. 5 ampoules in the outline of the cell. 2 contour packs with instructions for use, ampoule or ampoule with a knife in a pack of cardboard. 5 ampoules with the preparation complete with 5 ampoules of water for injections of 1 ml with the instruction for use, with a knife ampoule or scarifier ampullum in a pack or box of cardboard.5 ampoules with the preparation and 5 ampoules with water for injections of 1 ml in separate contour cell packs. 1 contour cell package with the preparation and 1 contour cell pack with water for injection with instructions for use, with a vial ampoule or ampoule knife in a pack of cardboard.

When packaging ampoules that have a break ring or an opening point, the ampoule knife or the ampoule scapegrator is not put in.

Storage conditions:

In the dark place at a temperature of no higher than 20 ° C.

Keep out of the reach of children.

Shelf life:3 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N001056 / 01

Date of registration:21.01.2008

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Information update date: & nbsp07.10.2015

Illustrated instructions

Instructions

Chondrolon® (Chondrolonum®)