Active substanceChondroitin sulfateChondroitin sulfate
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  • Dosage form: & nbspRAsterol for intramuscular injection.
    Composition:Per 1 ml:

    Active substance: chondroitin sodium sulfate (in terms of dry matter) - 100 mg;

    Excipients: gasoline alcohol - 9 mg, water for injection - up to 1 ml.
    Description:

    Transparent, colorless or slightly yellowish liquid with a smell of petrol alcohol.

    Pharmacotherapeutic group:tissue repair stimulant
    ATX: & nbsp

    M.01.A.X.25   Chondroitin sulfate

    Pharmacodynamics:

    High-molecular mucopolysaccharide, which affects the metabolic processes in the hyaline cartilage. The drug has chondroprotektivnym, stimulating the regeneration of cartilaginous tissue, anti-inflammatory effect. Participates in the construction of the main substance of cartilage and bone tissue, improves phosphoric-calcium metabolism in the cartilaginous tissue, inhibits enzymes that disrupt the structure and function of articular cartilage, inhibits the processes of degeneration of cartilaginous tissue.Stimulates the synthesis of proteoglycans, normalizes the metabolism of hyaline cartilage, promotes the regeneration of cartilaginous surfaces and the articular bag. Warns compression of connective tissue, increases the production of synovial fluid and mobility of affected joints, reduces concomitant inflammation, soreness, helps reduce the need for NSAIDs. With degenerative changes, cartilage tissue is a means of substitution therapy.

    The positive effect is observed already in 2-3 weeks after the beginning of the drug administration: pain in the joints decreases, the clinical manifestations of the reactive synovitis disappear, the volume of movements in the affected joints increases. The therapeutic effect persists for a long time (3-6 months) after the end of the course of treatment.

    Pharmacokinetics:

    Chondroitin sulfate is easily absorbed after intramuscular injection. Already 30 minutes after the injection, it is found in the blood in significant concentrations. The maximum concentration (CmOh) of chondroitin sulfate in plasma is achieved after 1 hour, then gradually decreases within 2 days.

    Chondroitin sulfate accumulates mainly in the cartilaginous tissue of the joints.Synovial membrane is not an obstacle to penetration of the drug into the joint cavity. 15 minutes after intramuscular injection chondroitin sulfate is found in the synovial fluid, then penetrates into the articular cartilage, where its content reaches a maximum after 48 hours.

    Indications:

    Degenerative and dystrophic diseases of the joints and spine:

    - osteoarthritis of peripheral joints;

    - intervertebral osteochondrosis and osteoarthrosis.

    To accelerate the formation of bone callus in fractures.

    Contraindications:

    - Hypersensitivity to the drug or its components;

    - tohemorrhage and tendency to bleeding, thrombophlebitis;

    - dEthnic age;

    - bVariability and lactation period (there are no data on the safety of the drug at present).

    Pregnancy and lactation:

    Currently, data on the use of the drug Chondroitin sulfate during pregnancy and lactation are absent.

    Dosing and Administration:

    The drug is administered intramuscularly by 1 ml (100 mg) every other day. With good tolerability, the dose is increased to 2 ml (200 mg), starting with the fourth injection. The course of treatment - 25-30 injections.If necessary, it is possible to conduct repeat courses in 6 months.

    For the formation of bone callus, the course of treatment is 3-4 weeks (10-14 injections every other day).

    Side effects:

    Allergic reactions are possible (skin itch, erythema, urticaria, dermatitis), hemorrhages at the injection site. In these cases, the drug is canceled.

    Overdose:At present, cases of an overdose of chondroitin sulfate have not been reported.
    Interaction:

    When the course of treatment with the drug Chondroitin sulfate should be cautious about the simultaneous use of anticoagulants direct action.

    It is also possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of blood coagulation indicators with simultaneous application.

    Special instructions:

    Use in Pediatrics

    Data on the efficacy and safety of chondroitin sulfate in children are currently not available.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and mechanisms.

    Form release / dosage:

    Solution for intramuscular injection, 100 mg / ml.

    Packaging:

    By 1 ml or 2 ml into neutral glass ampoules of grade НС-1 or НС-3.

    5 ampoules per circuit cell box made of polyvinyl chloride film and foil of aluminum printed lacquered or foil-free.

    1 or 2 contourcell packs with instructions for use and a scapegrator ampoule in a pack of cardboard.

    When packing ampoules with a ring of fracture or with a notch and a point, the ampoule scaper is not inserted.

    Storage conditions:

    In the dark place at a temperature of no higher than 20 ° C. Do not freeze.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-003946
    Date of registration:08.11.2016
    Expiration Date:08.11.2021
    The owner of the registration certificate:Medimeks, ZAOMedimeks, ZAO Russia
    Manufacturer: & nbsp
    Representation: & nbspBIOCHEMICAL JSC BIOCHEMICAL JSC Russia
    Information update date: & nbsp10.12.2016
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