Active substanceChondroitin sulfateChondroitin sulfate
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  • Dosage form: & nbspOintment for external use.
    Composition:
    Active substance - chondroitin sodium sulfate - 0.05 g (in terms of 100% dry matter); Excipients: dimethylsulfoxide (dimexide) 0.10 g, lanolin (lanolin anhydrous wax wax) 0.15 g, petroleum jelly 0.485 g, distilled mono glycerides 0.015 g, water (purified water) up to 1 g.
    Description:Ointment is light yellow with the smell of dimethylsulfoxide.
    Pharmacotherapeutic group:Reparation of tissue stimulant.
    ATX: & nbsp

    M.01.A.X.25   Chondroitin sulfate

    Pharmacodynamics:
    Chondroxide® ointment has a combined action:
    - slows the progression of osteoarthritis and osteochondrosis;
    - has analgesic effect;
    - has anti-inflammatory effect;
    - stimulates the restoration of articular cartilage;
    - improves the mobility of joints;
    - reduces swelling of the joints.

    Due to the optimal combination of the components of the ointment, there is a mutual increase in their analgesic and anti-inflammatory effects.The use of the drug Chondroxide®, ointment allows to reduce the dose of non-steroidal anti-inflammatory drugs taken. Chondroxide® contains a natural component chondroitin sulfate (high molecular weight mucopolysaccharide), which takes part in the construction of cartilaginous tissue. Chondroitin sulfate:

    - improves phosphoric-calcium metabolism in cartilaginous tissue;
    - reduces the activity of enzymes that destroy cartilaginous tissue;
    - inhibits the processes of degeneration (destruction) of cartilaginous tissue;
    - stimulates the synthesis of glucosaminoglycans;
    - prevents the collapse of connective tissue.

    This leads to a decrease in soreness and increased mobility of the affected joints.


    Pharmacokinetics:
    Chondroxide® ointment is well absorbed. According to the data obtained in experimental studies in mice using radiolabeled 3 H-chondroitin sulfate, the chondroitin sulfate absorption index is 14%. Dimethylsulfoxide It promotes a better penetration of chondroitin sulfate through cell membranes into the tissues. Chondroitin sulfate After applying the drug Chondroxide® ointment on the skin quickly and
    selectively enters the joint with reaching a maximum concentration after 30 minutes and the subsequent biphasic excretion of the drug from the cartilage tissue. Completion of fast phase
    withdrawal occurs 1 hour after application. Time of drug retention in the joint
    is 5 hours.

    Indications:Degenerative and dystrophic diseases of peripheral joints and spine: treatment and prevention of osteoarthritis, osteochondrosis of the spine.
    Contraindications:Hypersensitivity to the components of the drug. Damage to the skin in the area of ​​application.
    Carefully:Pregnancy, lactation, children's age (efficacy and safety not established).
    Dosing and Administration:Outwardly. Chondroxide® Ointment is applied 2-3 times a day to the skin above the lesion and rubbed for 2-3 minutes until completely absorbed. The course of treatment is from 2-3 weeks to 2-3 months. If necessary, repeat the course of treatment.
    Side effects:Allergic reactions.
    Overdose:
    No cases of an overdose of Chondroxide® ointment were reported.

    Interaction:Cases of interaction or incompatibility with other drugs are not described.
    Special instructions:Hondroxide® should be avoided on mucous membranes. Do not use the drug without consulting a doctor during pregnancy, during lactation, in childhood.
    Effect on the ability to drive transp. cf. and fur:
    Chondroxide® ointment does not cause sedation, psychomotor disorders and does not affect a patient's ability to engage in potentially dangerous activities requiring increased attention and speed of mental and motor reactions.

    Form release / dosage:Ointment for external use 5%.
    Packaging:
    For 30 or 50 g in tubes of aluminum or in tubes polyethylene laminate. Each tube together with instructions for medical use of the drug is placed in a pack of cardboard.

    Storage conditions:
    At a temperature of no higher than 25 ° C.
    Keep out of the reach of children.

    Shelf life:3 years. Do not use the drug after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LS-000640
    Date of registration:05.07.2010
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp29.09.2015
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