Ascorbic acid with glucose tablets 100 mg + 877 mg - instructions for use, dose, side effects, contraindications

Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting processes, tissue regeneration, and improves the body's resistance to infections.

Dextrose (glucose) is involved in various metabolic processes in the body.

Indications:

Prevention and treatment of hypo- and avitaminosis (scurvy). Provision of increased body requirement in vitamin C in the period of intensive growth, pregnancy, lactation, with intense physical and mental stress, stressful conditions, during recovery from long-term serious illnesses.

Contraindications:

Hypersensitivity to the drug. Do not administer large doses to patients with increased blood coagulability, thrombophlebitis and a tendency to thrombosis; with diabetes and conditions accompanied by high blood glucose. Contraindicated in children under 6 years.

Carefully:

Diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase; for use in large doses - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolythiasis.

Pregnancy and lactation:

Ascorbic acid penetrates the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a newborn can develop ascorbic disease as a withdrawal reaction. Therefore, in pregnancy, do not take ascorbic acid in elevated doses, except when the expected benefit exceeds the potential risk.

Ascorbic acid is excreted in breast milk. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent a deficiency in an infant. It is recommended not to exceed the maximum daily need for ascorbic acid by the nursing mother, unless the expected benefit exceeds the potential risk.

Dosing and Administration:

The drug is taken orally after a meal.

For preventive purposes, adults 1/2 (50 mg) - 1 (100 mg) tablet, children from 6 to 18 years of age on 1/2 (50 mg) tablets per day.

For medicinal purposes, adults 1/2 (50 mg) - 1 (100 mg) tablet 3-5 times a day, for children 1/2 (50 mg) - 1 (100 mg) 2-3 times a day.

The timing of treatment depends on the nature and course of the disease.

In pregnancy and during lactation, 3 tablets a day for 10-15 days, then 1 tablet a day.

Side effects:

Allergic reactions, irritation of the mucous membrane of the gastrointestinal tract (nausea, vomiting, diarrhea, spasm of the gastrointestinal tract); oppression of the insular pancreas function (hyperglycemia, glucosuria); when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate).

Changes in laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose:

Symptoms: with the use of more than 1 g - headache, increased central nervous system excitability, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa, suppression of the function of the insulin pancreas apparatus (hyperglycemia, glucosuria), hyperoxaluria. nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day).

Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

In case of taking a potentially toxic dose, vomiting is caused, in rare cases - the stomach is washed, Activated carbon, laxatives (for example, isotonic sodium sulfate solution).

Interaction:

Ascorbic acid: increases the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives).

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.

Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases. Acetylsalicylic acid reduces absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs quinoline series, calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the stores of ascorbic acid. With simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the excretion of mexiletine by the kidneys.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and lactate dehydrogenase).

Effect on the ability to drive transp. cf. and fur:

Does not affect the ability to drive vehicles and work with other mechanical means.

Form release / dosage:

Tablets (100 mg + 877 mg).

Packaging:For 10 tablets in a contour non-jellied package or in a contour mesh package.1, 2, 5 contour mesh or contour non-jawed packages with instructions for use are placed in a bundle. Contour non-cellular packages are placed in a group package with an equal number of instructions for use.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

1 year.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001199

Date of registration:11.11.2011

Expiration Date:Unlimited

The owner of the registration certificate:Tyumen Chemical - Pharmaceutical Plant, OJSC Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Manufacturer: & nbsp

Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Information update date: & nbsp27.09.2017

Illustrated instructions

Instructions

Ascorbic acid with glucose tablets 100 mg + 877 mg (Ascorbic acid with glucose tablets 100 mg + 877 mg)