Ascorbic acid with glucose - instructions for use, dose, side effects, contraindications

Ascorbic acid plays an important role in regulation, redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and improves the body's resistance. Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food. With a balanced and nutritious diet, a person does not experience a deficiency in vitamin C.

Dextrose (glucose) is involved in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver. It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

Indications:

Prevention and treatment of hypovitaminosis C. Provision of increased body requirement in vitamin C in the period of intensive growth, pregnancy, breastfeeding,with increased physical and mental stress, stressful conditions, in the period of recovery after long and severe diseases.

Contraindications:

Hypersensitivity to the components of the drug, children up to 3 years.

Carefully:

Diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase; when used in large doses - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolythiasis.

Dosing and Administration:

The drug is taken orally after a meal.

Doses are given in terms of ascorbic acid.

With the preventive purpose of appoint:

Adults - 50-100 mg / day (1/2 - 1 tablet).

With a therapeutic purpose appoint:

Adults - 50-100 mg / day 3-5 times a day; children 50-100 mg 2-3 times in a day.

During pregnancy and lactation - 300 mg / day (3 tablets) for 10-15 days, then 100 mg (1 tablet) per day.

The timing of treatment depends on the nature and course of the disease and is recommended doctor.

Side effects:

Allergic reactions to the components of the drug are possible; irritation of the mucous membrane of the gastrointestinal tract (diarrhea, vomiting, spasm of the gastrointestinal tract); oppression of the insular pancreas function (hyperglycemia, glucosuria); when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate).Changes in laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose:

Symptoms: when using more than 1 g - headache, increased central nervous system excitability, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa, suppression of the function of the insulin pancreas apparatus (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day).

Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Treatment: symptomatic.

Interaction:

Ascorbic acid: increases the concentration in. blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives).

Improves absorption in the intestines of drugs, iron (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.

Reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases.

Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%.

Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body;

Medicinal products of the quinolone series, salicylates, glucocorticosteroid agents with long-term use deplete the stores of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, it may interfere with the interaction disulfiram - ethanol.

In high doses increases the excretion of mexiletine by the kidneys.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure. With prolonged use of large doses, it is possible to suppress the function of the insulin apparatus of the pancreas, so during the treatment it is necessary to regularly monitor the functional capacity of the pancreas. Persons with a deficiency of glucose-6-phosphate dehydrogenase should be administered with caution. In patients with elevated iron levels in the body should be used ascorbic acid in minimal doses. Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid as the reductant can distort the results of various laboratory tests (blood glucose, bilirubin, the activity of "liver" transaminases and lactate dehydrogenase).

The drug contains dextrose (glucose) monohydrate, which should be borne in mind when prescribing to patients with diabetes mellitus.

The amount of carbohydrates in the maximum daily dose is: for adults - 0.37 XE; for children - 0,22 ХЕ; during pregnancy and lactation - 0.07 XE.

Effect on the ability to drive transp. cf. and fur:

The drug has no effect on the ability to drive vehicles and to engage in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Tablets of ascorbic acid with glucose [100 mg + 877 mg].

Packaging:

For 10 tablets in a contour non-cellular package made of paper with polyethylene coating or in a contour cell packaging made of polyvinylchloride film EP-73 and aluminum foil printed lacquer.

2 or 3 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Contour non-cellular packages, together with an equal number of instructions for use, are placed in a group package.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

1 year. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000073

Date of registration:12.02.2010 / 18.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp26.09.2017

Illustrated instructions

Instructions

Ascorbic acid with glucose (Ascorbic acid with glucose)