Ascorbic acid with glucose - instructions for use, dose, side effects, contraindications

Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration, and improves the body's resistance. Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food. With a balanced and nutritious diet, a person does not experience a deficiency in vitamin C.

Dextrose is involved in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver. It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

Indications:

Prevention of Vitamin C hypovitaminosis. Providing increased body requirement for vitamin C during growth, pregnancy, breastfeeding,with high physical and mental stress, with fatigue, during recovery after long and severe illness.

Contraindications:

Hypersensitivity to the components of the drug, children's age (up to 3 years). Do not administer large doses to patients with high blood coagulability, thrombophlebitis and a tendency to thrombosis, as well as diabetes and conditions accompanied by high blood sugar.

Carefully:

Hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolythiasis (when used in large doses); deficiency of glucose-6-phosphate dehydrogenase.

Pregnancy and lactation:

Ascorbic acid penetrates the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a newborn can develop ascorbic disease as a withdrawal reaction. Therefore, in pregnancy, do not take ascorbic acid in elevated doses, except when the expected benefit exceeds the potential risk.

Ascorbic acid is excreted in breast milk.A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent her deficiency in an infant. It is recommended not to exceed the maximum daily need for ascorbic acid by the nursing mother, unless the expected benefit exceeds the potential risk.

Dosing and Administration:

The drug is taken orally after a meal.

With the preventive purpose of appoint:

Adults - ½ - 1 tablet per day.

During pregnancy and lactation, 3 tablets per day for 10-15 days, then 1 tablet a day.

With a therapeutic purpose appoint:

Adults take ½ to 1 tablet 3-5 times a day.

Children - 1/2 - 1 tablet 2-3 times a day.

The duration of treatment depends on the nature and course of the disease and is recommended by a doctor.

Side effects:Allergic reactions to the components of the drug are possible. Hypervitaminosis of vitamin C. Irritation of the mucous membrane of the gastrointestinal tract (nausea, vomiting, diarrhea, spasm of the gastrointestinal tract); oppression of the insular pancreas function (hyperglycemia, glucosuria); when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate).Change in laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose:

Symptoms: with prolonged use of large doses (more than 1 g) - headache, increased central nervous system excitability, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa, suppression of the function of the insulin pancreas apparatus (hyperglycemia, glucosuria) , hyperoxaluria. nephrolithiasis, (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day). Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Treatment: In case of taking a potentially toxic dose, vomiting is caused, in rare cases - the stomach is washed, Activated carbon, laxatives (for example, isotonic sodium sulfate solution).

Interaction:Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including that of oral contraceptives).

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.

Reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases. Acetylsalicylic acid reduces absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including number of alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs quinoline series, calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the stores of ascorbic acid.With simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the excretion of mexiletine by the kidneys, reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the formation of glucocorticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure. With prolonged use of large doses, it is possible to suppress the function of the insulin apparatus of the pancreas, so during the treatment it is necessary to regularly monitor the functional capacity of the pancreas.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles, work with precise mechanisms and engage in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Pills. Ascorbic acid - 0.1 g + Dextrose - 0.877 g.

Packaging:

For 10 tablets in a contour non-cellular package of packaging paper.

For 10 tablets in a contour mesh box made of polyvinylchloride film and foil of aluminum printed lacquered or paper packaging.

2, 3 contourcell packings with tablets labeled "R" with instructions for use put in a pack of cardboard.

By 2, 3 contour cell packs with tablets without labeling "R" with instructions for use put in a pack of cardboard.

For 20 contour non-jawed or contiguous cell packs with tablets without labeling "R" with an equal number of instructions for use are placed in a pack of cardboard.

Contourless cell-free or contiguous cell packs with tablets without labeling "R" with an equal number of instructions for use are placed in a group package.

Storage conditions:

In a pack, in a dry place at a temperature of no higher than 25 ° С (for tablets packed in 2, 3 contour packs in a pack or 20 contour cell / non-cellular packages in a pack).

In dry, dark place at a temperature of no more than 25 ° C (for tablets packed in a contour mesh / cellless packaging).

Keep out of the reach of children.

Shelf life:2 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-005262/07

Date of registration:25.12.2007 / 14.05.2015

Expiration Date:Unlimited

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Information update date: & nbsp17.10.2017

Illustrated instructions

Instructions

Ascorbic acid with glucose (Ascorbic asid with glucose)