Ascorbic acid with glucose (Ascorbic asid with glucose)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAscorbic acid + DextroseAscorbic acid + Dextrose
Dosage form: & nbsppills
Composition:

Active components:

ascorbic acid 0.1 g, glucose (dextrose) 0.877 g.

Excipients: talcum, calcium stearate.

Description:Ploskotsilindricheskie tablets of white color with a facet and a risk.
Pharmacotherapeutic group:Vitamin
ATX: & nbsp

A.11.G.B   Ascorbic acid in combination with other drugs

Pharmacodynamics:

Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulability, tissue regeneration, contributes to the body's resistance, reduces vascular permeability, and participates in the synthesis of steroid hormones. Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food. With a balanced and nutritious diet, a person does not experience a deficiency in vitamin C.

Dextrose provides energy metabolism. With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

Indications:

Prevention and treatment of hypo - and vitamin deficiency Vitamin C. Providing increased body requirement for vitamin C during growth, pregnancy, breastfeeding, with high physical and mental stress, fatigue, stressful conditions, during recovery from long and severe diseases.

Contraindications:

Hypersensitivity to the components of the drug.Do not administer large doses to patients with high blood coagulability, thrombophlebitis and a tendency to thrombosis, as well as diabetes and conditions accompanied by high blood sugar. Children under 3 years (for this dosage form).

Carefully:

Deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, nephrolithiasis, pregnancy.

Dosing and Administration:

The drug is taken orally after a meal. With the preventive purpose of appoint:

Adults - 50-100 mg / day. During pregnancy and lactation at 300 mg / day. for 10-15 days, then for 100 mg / day.

With a therapeutic purpose appoint:

Adults - 50-100 mg / day, 3-5 times a day; children 50-100 mg / day 2-3 times a day.

The timing of treatment depends on the nature and course of the disease and is recommended by the doctor.

Side effects:

Allergic reactions to the components of the drug are possible.

From the digestive system: irritation of the mucosa GIT.

Allergic reactions: skin rash, skin hyperemia.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Overdose:

Symptoms: with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa, oppression of the insular pancreas (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day); Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulability, development of microangiopathies).

Interaction:

Ascorbic acid increases the absorption of drugs of the penicillin group, iron, the concentration in the blood of benzylpenicillin and tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives). Reduces the effectiveness of heparin and non-direct anticoagulants. Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce absorption and absorption.

With simultaneous use with acetylsalicylic acid increases excretion of ascorbic acid with urine and reduction of excretion of acetylsalicylic acid.

Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%.

Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

The drugs of quinoline series, calcium chloride, salicylates, glucocorticosteroids with long-term use deplete the stores of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.

With prolonged use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the excretion of mexiletine by the kidneys. Barbiturates and primidon increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine,tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure. With prolonged use of large doses, it is possible to suppress the function of the insulin apparatus of the pancreas, so during the treatment it is necessary to regularly monitor the functional capacity of the pancreas. Persons with a deficiency of glucose-6-phosphate dehydrogenase should be used with caution.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and LDH).

The minimum daily requirement for ascorbic acid in II-III trimesters of pregnancy - about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then a "cancellation" syndrome may develop in a newborn.

The minimum daily requirement for lactation is 80 mg. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent a deficiency in an infant. Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily need for ascorbic acid by the nursing mother).

Form release / dosage:

Tablets 100 mg + 877 mg.

Packaging:

By 10 tablets into a contoured cell packaging made of a polyvinylchloride film and aluminum foil or a contiguous, non-jagged packing made of paper with a polymer coating or with a polyethylene coating or aluminum foil.

For 30 or 40 tablets in cans or bottles of light-protective glass with a triangular corolla or cans of OS with a screw neck or in bottles of glass glass of light-protective glass.

To the bank, the bottle, 1,2,3,4,5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Contour non-cellular packages with an equal number of instructions for use are placed in a group package.
Storage conditions:

In a dry, dark place at a temperature of 10 ° C to 25 ° C.Keep out of the reach of children.

Shelf life:

1 year. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:LSR-004205/08
Date of registration:30.05.2008
Expiration Date:Unlimited
The owner of the registration certificate:EVROFARM, CJSC EVROFARM, CJSC Russia
Manufacturer: & nbsp
Information update date: & nbsp27.09.2017
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