Ascorbic acid increases absorption of penicillin and iron. Increases the concentration in the blood of tetracyclines; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline draw reduce the absorption and absorption of ascorbic acid.
With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases.Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short acts, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.
Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
With simultaneous use reduces the chronotropic effect of isoprenaline.
With long-term use or use in high doses, break down, the interaction of disulfiram-ethanol.
In high doses increases the excretion of mexiletine by the kidneys.
Barbiturates and primidon increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.