Ascorbic acid with glucose (Ascorbic acid with glucose)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAscorbic acid + DextroseAscorbic acid + Dextrose
Dosage form: & nbsppills
Composition:

Composition per 1 tablet:

Active substances:

Ascorbic acid - 100 mg

Dextrose monohydrate (glucose) - 877 mg

Excipients:

Calcium stearate -10 mg

Potato starch - 5 mg

Talc - 8 mg

Weight of the tablet - 1000 mg

Description:Tablets of white color with a flat-cylindrical shape.
Pharmacotherapeutic group:Vitamin
ATX: & nbsp

A.11.G.B   Ascorbic acid in combination with other drugs

Pharmacodynamics:

Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration, and improves the body's resistance. Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food. With a balanced and nutritious diet, a person does not experience a deficiency in vitamin C.

Dextrose is involved in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver. It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

Indications:

Provision of increased body requirement in vitamin C in the period of intensive growth, pregnancy, breastfeeding, with increased physical and mental stress, stressful conditions, during recovery after long and severe diseases.

Contraindications:

Hypersensitivity to the components of the drug. Do not administer large doses to patients with increased blood coagulability, thrombophlebitis, and a tendency to thrombosis, as well as diabetes and conditions accompanied by high blood sugar. Children under 6 years.

Carefully:

Deficiency of glucose-6-phosphate dehydrogenase; when used in large doses - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolythiasis.

Dosing and Administration:

The drug is taken orally after a meal.

With preventive purpose appoint: adults 50-100 mg / day;

children from 6 to 14 years - 50 mg / day, from 14 to 18 years - 75 mg / day;

during pregnancy and lactation at 300 mg / day for 10-15 days, then 100 mg / day.

With the therapeutic purpose appoint: adults 50-100 mg / day 3-5 times a day; children 50-100 mg 2-3 times a day.

The maximum daily dose for adults is 1000 mg, for children - 500 mg.

The timing of treatment depends on the nature and course of the disease and is recommended by the doctor.

Side effects:

Possible allergic reactions to the components of the drug, irritation of the mucous membrane of the gastrointestinal tract (nausea, vomiting, diarrhea,spasm of the gastrointestinal tract); oppression of the insular pancreas function (hyperglycemia, glucosuria); when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate). Changes in laboratory parameters: thrombocytosis, giperprotrombinemiya, erythropenia, leukocytosis, hypokalemia.

Overdose:

Symptoms: The use of more than 1 g - headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract, inhibition insular pancreatic apparatus function (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), renal glomerular damage apparatus moderate pollakiuria (when receiving a dose of 600 mg / day).

Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Interaction:

Ascorbic acid concentration in blood increases penicillin and tetracycline.

Improves the absorption of iron preparations.

Slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids).

Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Drugs quinoline, calcium chloride, glucocorticosteroids with prolonged use deplete the stores of ascorbic acid.

With simultaneous use reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, it can disrupt the interaction of disulfiram-ethanol.

In high doses increases the excretion of mexiletine by the kidneys.

Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:

In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure.

With prolonged use of large doses, oppression of the insulin function of the pancreas is possible, so during treatment it must be regularly monitored.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and lactate dehydrogenase).

Patients with diabetes should take into account that one tablet contains about 0.08 XE, in a daily dose (5 tablets) - contains about 0.4 XE.

Effect on the ability to drive transp. cf. and fur:No data available.
Form release / dosage:

Tablets 100 mg + 877 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

For 10 tablets in a contour non-jawed packaging made of material combined on paper and cardboard basis with polyethylene coating, or combined material "Buflen".

By 1, 2, 4, 6, 10 contour mesh or contour non-jawed packages together with the instruction for use are placed in a pack of consumer paperboard or a hermetically sealed plastic bag made of light-proof polyethylene film or a bag of material combined on paper and cardboard basis with polyethylene coating, or the material of the combined "Bufleen".

5, 10, 20, 50, 100, 200, 400, 500, 600 contour mesh or contour non-jawed packages together with an equal number of instructions for use in a hermetically sealed polyethylene bag made of light-proof polyethylene film.

It is allowed to put the full text of the instructions for use on the contour non-jawed packaging, bundle, bag.

Polyethylene bags are placed in a cardboard box.
Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

In a place inaccessible to children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:PL-000311
Date of registration:21.02.2011
Expiration Date:21.02.2016
The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia
Manufacturer: & nbsp
Information update date: & nbsp26.09.2017
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