Active substancePotassium and magnesium asparaginatePotassium and magnesium asparaginate
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  • Dosage form: & nbsppills
    Composition:

    1 tablet contains:

    active substances: magnesium aspartate tetrahydrate - 175 mg, potassium asparaginate hemihydrate-175 mg;

    Excipients: corn starch, calcium stearate, talc.
    Description:Tablets of white color, round, flat-cylindrical, with a risk and a facet.
    Pharmacotherapeutic group:Potassium and magnesium preparation
    ATX: & nbsp

    A.12.C.X   Preparations of other minerals

    Pharmacodynamics:

    Asparta is a source of potassium ions (K+) and magnesium (Mg2+), regulates metabolic processes, helps to restore electrolyte balance, has antiarrhythmic effect. Potassium is involved in carrying out pulses along the nerve fibers, and in synaptic transmission, implementing muscle contractions, maintaining normal cardiac activity. Violation of potassium metabolism leads to a change in the excitability of nerves and muscles. Active ion transport maintains a high K gradient+ through the plasma membrane.In small doses of K+ expands coronary arteries, in large - narrows. Has a negative, chrono- and batmotropic effect, in high doses - a negative foreign and dromotropic, as well as a moderate diuretic effect.

    Mg2+ is a cofactor of 300 enzyme reactions. An irreplaceable element in processes that ensure the receipt and consumption of energy. Participates in the balance of electrolytes, transport of ions, permeability of membranes, neuromuscular excitability. Included in the structure (pentose-phosphate) DNA, participates in the synthesis of RNA, the apparatus of heredity, cell growth, in the process of cell division. Limits and prevents excessive release of catecholamine during stress, lipolysis and release of free fatty acids are possible. It is a "physiological" blocker of slow calcium channels. Promotes penetration of K+ in the cells.

    Aspartate promotes penetration of K+ and Mg2+ Intracellular space; stimulates the intercellular synthesis of phosphates.

    Pharmacokinetics:

    Asparkam after ingestion is characterized by high absorption. It is excreted by the kidneys.

    Indications:Replenishment of potassium and magnesium deficiency (as part of complex therapy), including ischemic heart disease, chronic heart failure; disturbances of the rhythm of the heart (including, against the background of an overdose of cardiac glycosides).
    Contraindications:

    Hypersensitivity to magnesium asparaginate and potassium asparaginate, acute and chronic renal failure, hyperkalemia, hypermagnesia, insufficiency of the adrenal cortex, atrioventricular block II-III degree, impairment of amino acid metabolism, hemolysis, severe myasthenia gravis, arterial hypotension (systolic blood pressure less than 90 mm Hg), age under 18 years (efficacy and safety not established).

    Carefully:During pregnancy and lactation.
    Pregnancy and lactation:

    Apply with caution if the need for the expected therapeutic effect exceeds the potential risk to the fetus or child.

    Dosing and Administration:Is inside, after eating 1-2 tablets 3 times a day. The course of treatment is 3-4 weeks, if necessary, repeat the course.
    Side effects:

    Hyperkalemia (nausea, vomiting, diarrhea,paresthesia) and hypermagnia (hyperemia of the facial skin, thirst, bradycardia, lowering of arterial pressure, atrioventricular blockade, muscle weakness, fatigue, paresis, coma, areflexia, respiratory depression, convulsions); nausea, vomiting, diarrhea, pain in the epigastric region (in patients with an anatomic gastritis or cholecystitis).

    Overdose:

    Symptoms: hyperkalemia (nausea, vomiting, diarrhea, paresthesia) and hypermagnia (facial skin hyperemia, thirst, bradycardia, lowering of blood pressure, muscle weakness, fatigue, paresis, coma, areflexia, hyporeflexia, respiratory depression, seizures); conduction disturbance, especially with the previous pathology of the conduction system of the heart, atrioventricular blockade.

    Treatment: intravenously - calcium chloride, if necessary - hemodialysis and peritoneal dialysis.

    Interaction:

    Pharmacodynamic interaction. Potassium-sparing diuretics (triamterene, spironolactone and others), beta-blockers, ciclosporin, heparin, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs increase the risk of hyperkalemia up to the development of arrhythmia and asystole.Anesthetics increase the inhibitory effect of magnesium on the central nervous system. Calcium preparations reduce the effects of magnesium.

    Drugs of potassium eliminate hypokalemia caused by glucocorticosteroids. Aspartame reduces unwanted effects of cardiac glycosides. Due to the content of magnesium ions asparkam reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin; can enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracurium bezylate, decamethonium bromide, suxamethonium (chloride, bromide, iodide).

    Pharmacokinetic interaction. Calcitriol increases the concentration of magnesium in the blood plasma. Astringent and enveloping medicinal agents reduce the absorption of the drug in the gastrointestinal tract (it is necessary to observe a 3-hour interval between their intake).

    Special instructions:

    When long-term use is recommended to monitor the potassium and magnesium concentrations in the blood and the electrocardiogram parameters. Preparations of potassium at intake can irritate a mucous membrane of a gastrointestinal tract, therefore it is not recommended to accept a preparation on an empty stomach.In patients with adrenal insufficiency, the risk of hyperkalemia increases.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Pills.
    Packaging:

    For 10 or 50 tablets in a contour mesh package.

    The outline pack of 50 tablets or 5 contiguous cells packs of 10 tablets together with instructions for medical use are placed in a pack of cardboard.
    Storage conditions:

    Store in a dry place at a temperature of 15 ° C to 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:П N014692 / 01-2003
    Date of registration:22.04.2008 / 24.08.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine
    Manufacturer: & nbsp
    Information update date: & nbsp27.09.2017
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