Asparkam - instructions for use, dose, side effects, contraindications

Description:Round flat cylindrical tablets white or white with a yellowish tint of color with a facet and a risk. On the surface of the tablets, slight marbling is allowed.

Pharmacotherapeutic group:Potassium and magnesium preparation

ATX: & nbsp

A.12.C.X Preparations of other minerals

Pharmacodynamics:

The most important intracellular cations of potassium and magnesium play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions has an effect on myocardial contractility. Endogenous asparaginate acts as an ion conductor: it has a high affinity for cells, due to the insignificant dissociation of its salts,ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium asparaginate improve myocardial metabolism.

The lack of magnesium / potassium predisposes to the development of arterial hypertension, coronary artery atherosclerosis, arrhythmias and metabolic changes in the myocardium.

Pharmacokinetics:

Potassium asparaginate and magnesium asparaginate are absorbed intensively in the intestine, mainly in the intestine. They are excreted by the kidneys.

Indications:

To eliminate the deficiency of potassium and magnesium in the combination therapy for various manifestations of coronary heart disease (including myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).

Contraindications:

Hypersensitivity to any of the components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesia, Addison's disease, atrioventricular blockade I-III degree, shock (including cardiogenic), arterial hypotension (arterial pressure less than 90 mm Hg), impaired metabolism of amino acids, severe myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration,age under 18 years (efficacy and safety not established), the period of breastfeeding.

Carefully:

Simultaneous use with drugs that can cause hyperkalemia (see section "Interaction with other drugs"), pregnancy, the period of breastfeeding, violations of the water-electrolyte balance.

Pregnancy and lactation:

Adequate and strictly controlled studies of the use of the drug during pregnancy and during breastfeeding were not conducted.

Use Asparkam during pregnancy is possible if the potential benefit to the mother exceeds the possible risk to the fetus / child.

Potassium and magnesium aspartate penetrate into breast milk. If you need to use the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

Before using Asparks, you should consult your doctor. The drug should be taken orally, with plenty of water, without chewing. Take after meals, tk. The acidic environment of the stomach reduces its effectiveness.

Take 1 tablet 3 times a day.

Maximum dose: 3 tablets per day.

Duration of the course of treatment and repeated courses - on the recommendation of a doctor.

Side effects:

Disorders from the gastrointestinal tract: nausea, vomiting, diarrhea, dry mouth, abdominal pain, flatulence, ulceration of the mucous membrane of the gastrointestinal tract.

Heart Disease: atrioventricular blockade, paradoxical reaction (increase in the number of extrasystoles).

Laboratory and instrumental data: hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnia (redness of the face, thirst, lowering of blood pressure, hyporeflexia, respiratory depression, convulsions).

General disorders and disorders at the site of administration: asthenia, increased sweating.

Disturbances from the skin and subcutaneous tissues: itching.

Disturbances from the respiratory system, organs of the thorax and mediastinum: dyspnoea.

If any of the listed adverse reactions become serious, oozeand you will notice the appearance of adverse reactions not listed in this manual, You should see a doctor.

Overdose:

There is a growing risk of symptoms of hyperkalemia and hypermagnesemia.

Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, heart rhythm disturbances (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).

Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, lowering of blood pressure.

With a sharp increase in the content of magnesium ions in the blood: depression of deep tendon reflexes, respiratory paralysis, coma.

Treatment: symptomatic therapy - intravenous calcium chloride at a dose of 100 mg / min. if necessary, hemodialysis.

Interaction:

Patients who take asparagus together with the drug Asparagus should also inform the doctor about this.

Pharmacodynamic interaction

When combined with potassium-sparing diuretics (for example, spironolactone, eplerenone, triamterene. amyloride), beta adrenoblockers, cyclosporine, heparin, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs increases the risk of hyperkalemia up to the development of arrhythmia and asystole.

Simultaneous use of potassium preparations with glucocorticosteroids eliminates hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides.

The drug enhances the negative dromo- and batmotropic effect of antiarrhythmic drugs.

Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the oppressive effect of magnesium preparations on the central nervous system; when used simultaneously with atrakuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in blood plasma, calcium preparations reduce the effects of magnesium preparations.

Pharmacokinetic interaction

Medicines with astringent and enveloping action reduce the absorption of magnesium asparaginate and potassium asparaginate in the gastrointestinal tract, so it is necessary to observe a three-hour interval between ingestion of the drug with the above medicines.

Special instructions:

Particular attention is required by patients with diseases accompanied by hyperkalemia: regular monitoring of the potassium content in the blood plasma is necessary.

When used simultaneously with drugs that can increase the potassium content in the blood, regular monitoring of the content of cadia, in blood plasma (see section "Interaction with other drugs") is necessary.

When skin pruritus and skin flushing occur, weakness in muscles should be stopped and consult a doctor.

Effect on the ability to drive transp. cf. and fur:

The influence of Asparkam on the ability to control vehicles and mechanisms has not been studied. It is not expected to influence the ability to drive vehicles and work with mechanisms that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Tablets 175 mg + 175 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

10, 20, 30, 50, 56, 60 or 100 tablets in cans of polyethylene terephthalate or polypropylene for drugs sealed with high-pressure polyethylene caps with a first opening control or polypropylene caps with a "push-turn" system or with low-density polyethylene caps pressure with the control of the first opening.

One jar or 1, 2, 3, 5, 6 or 10 contour mesh packages together with the instruction for use are placed in a cardboard package (bundle).

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-004628

Date of registration:12.01.2018

Expiration Date:12.01.2023

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZON PHARM, LLC Russia

Information update date: & nbsp20.02.2018

Illustrated instructions

Instructions

Aspark (Asparcam)