Potassium and magnesium asparaginate Berlin-Chemie - instructions for use, dose, side effects, contraindications

The preparation of potassium and magnesium asparaginate Berlin-Chemie is a source of potassium and magnesium ions. Eliminates the deficiency of potassium and magnesium, normalizes the electrolyte balance, improves the metabolism in the myocardium. The mechanism of action of the drug is associated with the participation of aspartate in the transport of magnesium and potassium ions into the intracellular space. Magnesium activates sodium potassium-ATPase, removing sodium ions from the cell and returning the potassium ions; reduces the sodium content and prevents its exchange with calcium in the smooth muscle of the vessels, reducing their resistance.Potassium stimulates the synthesis of ATP, glycogen, proteins, acetylcholine. Both ions support the polarization of cell membranes. The drug regulates the conduct of impulses along nerve fibers, synaptic transmission, muscle contraction, the work of the heart muscle. Due to magnesium ions it participates in the processes of energy input and consumption, normalizes membrane permeability, neuromuscular conductivity, oxygen uptake and synthesis of phosphates.

Indications:To eliminate the deficiency of potassium and magnesium in the combination therapy for various manifestations of coronary heart disease, including acute myocardial infarction; chronic circulatory failure; disturbances of the heart rhythm (tachyarrhythmias, extrasystole, including arrhythmias due to intoxication with cardiac glycosides).

Contraindications:

- hypersensitivity to the components of the drug;

- severe renal dysfunction;

- Hyperkalemia;

- hypermagnesia;

- hemolysis;

- oliguria, anuria;

- arterial hypotension;

- Insufficiency of adrenal cortex function;

- Addison's disease;

- shock;

- Acute metabolic acidosis;

- dehydration;

- atrioventricular blockade of II and III degree;

- Myasthenia gravis;

- age under 18 years (efficacy and safety in children under 18 years of age have not been studied).

Carefully:

- Progressive liver failure;

metabolic acidosis;

- the risk of edema;

- Decreased kidney function when it is not possible to regularly monitor the magnesium content in the blood serum (the danger of cumulation and magnesium increase to a toxic level);

- hypophosphatemia;

- a violation of the exchange of calcium, magnesium and ammonium phosphate with a tendency to form concretes;

- pregnancy and lactation.

Pregnancy and lactation:

Studies on the safety of the use of the drug potassium and magnesium asparaginate Berlin-Chemie in pregnancy has not been carried out, so this drug can be used only for vital indications.

Since it is not known whether potassium and magnesium penetrate asparaginate into breast milk, caution should be exercised when using the drug during lactation.

Dosing and Administration:

For intravenous use.

The dose of the drug is selected individually and depending on the indications.

If there are no other appointments,then 1-2 injections of 500 ml of the preparation of potassium and magnesium asparaginate Berlin-Chemie per day are recommended. Rate of administration: 15-45 drops per minute, depending on individual tolerability.

One week before the cardiosurgical intervention and then within a week after it, 500 ml of the preparation of potassium and magnesium are administered asparaginate Berlin-Chemie once a day.

Treatment with the drug can be continued for several days before the disappearance or reduction of pathological symptoms.

Side effects:

When observing the recommended speed of drip, side effects were not observed.

With rapid intravenous administration, symptoms of hyperkalemia and hypermagnesemia may arise: nausea, vomiting, muscle weakness. From the central nervous system: paresthesia, paresis, hyporeflexia, coma; from the cardiovascular system: bradycardia, arrhythmia, hypotension, paradoxical increase in the number of extrasystoles, atrioventricular blockade.

Side effect of a toxic nature was not observed.

Overdose:

Overdose is possible with too rapid administration or when the drug is administered in doses that are significantly higher than recommended.Symptoms of hyperkalemia: general weakness, paresthesia of the lower extremities, impaired sensitivity, confusion, bradycardia, arrhythmias, hypotension, vascular collapse up to ventricular fibrillation and cardiac arrest in diastole. Symptoms of hypermagnesemia: nausea, vomiting, lethargy, atony of the bladder, constipation; deterioration of atrioventricular conduction and propagation of excitation in the ventricles; the extinction of deep tendon reflexes, a drop in blood pressure, and respiratory depression.

Treatment: immediate withdrawal of the drug, the introduction of a solution of sodium chloride 20% or calcium gluconate 10%; for the correction of cardiovascular disorders, symptomatic therapy is indicated, if necessary, hemodialysis or peritoneal dialysis.

Interaction:

The combined use of potassium-sparing diuretics and / or angiotensin-converting enzyme (ACE inhibitors) can lead to niperculoemia and hypermagnesia.

Special instructions:

Use only clear solutions in intact vials! After opening the bottle with the preparation of potassium and magnesium, asparaginate Berlin-Chemie it must be used immediately.

Intravenous administration of the drug should be slow.If, when mixed with other injectable or infusion solutions, turbidity or opalescence appears, these mixtures can not be used for safety reasons.

Effect on the ability to drive transp. cf. and fur:

It is not known.

Form release / dosage:

Solution for infusion.

Packaging:

For 250 or 500 ml of the drug in vials:

1) of transparent glass type II, closed with a bromobutyl rubber stopper for piercing and a plastic lid under an aluminum run-off and with a plastic holder fixed on the vial.

2) from low-density polyethylene, with a cap welded onto the bottle, with an integrated rubber gasket and two rings for opening and with a holder on the bottom of the bottle.

For 10 vials in a cardboard box with the appropriate number of instructions for use (for hospitals).

Storage conditions:

Store at a temperature not exceeding 25 ° C. Do not freeze!

Keep out of the reach of children!

Shelf life:

3 years.

Use only clear solutions in intact vials!

After opening the vial the drug should be immediately used!

Do not use after the expiration date stated on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N012305 / 01

Date of registration:11.09.2012 / 23.04.2014

Expiration Date:Unlimited

The owner of the registration certificate:BERLIN-PHARMA, CJSC BERLIN-PHARMA, CJSC Russia

Manufacturer: & nbsp

BERLIN-CHEMIE, AG Germany

Representation: & nbspBERLIN-CHEMI / MENARINI PHARMA GmbH BERLIN-CHEMI / MENARINI PHARMA GmbH Germany

Information update date: & nbsp26.11.2017

Illustrated instructions

Instructions

Potassium and magnesium asparaginate Berlin-Chemie (Potassium-magnesium asparaginate Berlin-Chemie)