Asparkam - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Asparta is a source of potassium and magnesium ions, regulates metabolic processes. The mechanism of action is presumably associated with the role of aspartate as a carrier of magnesium and potassium ions in the intracellular space and with the participation of aspartate in metabolic processes. Thus, asparks eliminates the imbalance of electrolytes, reduces the excitability and conductance of the myocardium (moderate antiarrhythmic effect).

Pharmacokinetics:

Easily absorbed when ingested and relatively quickly excreted by the kidneys.

Indications:

Asparta is used in the complex therapy of chronic heart failure; ischemic heart disease, hypokalemia, cardiac rhythm disturbances (including myocardial infarction, cardiac glycoside overdose).

Contraindications:

- Hypersensitivity to the drug;

- impaired metabolism of amino acids;

- acute and chronic renal failure;

- hyperkalemia;

- hypermagnesia;

- insufficiency of the adrenal cortex;

- disturbance of atrioventricular conduction (atrioventricular block I - III c);

- severe myasthenia gravis;

- hemolysis;

- arterial hypotension;

- age under 18 years (no data).

Pregnancy and lactation:During pregnancy and lactation.

Dosing and Administration:

Asparkam is prescribed inside, after eating 1-2 tablets 3 times a day.

The course of treatment is 3-4 weeks. If necessary, repeat the course.

Side effects:

Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with an anatomic gastritis or cholecystitis), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnia (reddening of the face, thirst, lowering blood pressure, hyporeflexia, muscle weakness, paresis, coma, areflexia, respiratory depression, convulsions).

Overdose:

Symptoms: conduction disturbance (especially with the previous pathology of the conduction system of the heart).

Treatment: intravenous calcium chloride; if necessary, hemodialysis and peritoneal dialysis.

Interaction:

Pharmacodynamic: joint application with potassium-sparing diuretics (triamterene, spironolactone), beta-adrenoblockers, cyclosporine, heparin, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs increases the risk of hyperkalemia up to the development of arrhythmia and asystole.

The use of potassium preparations together with glucocorticosteroids eliminates the hypokalemia caused by the latter.

Due to the content of potassium ions, the undesirable effects of cardiac glycosides decrease. Due to the content of magnesium ions reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin.

At simultaneous application the preparation can strengthen the neuromuscular blockade caused by depolarizing muscle relaxants (atrakury bezilatom, decamethonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the content of magnesium ions in the blood plasma; Calcium preparations reduce the effect of magnesium preparations.

Pharmacokinetic: astringents and enveloping agents reduce the absorption of the drug in the gastrointestinal tract (it is necessary to observe a 3-hour interval, between their reception).

Form release / dosage:Pills.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and foil of aluminum printed lacquered or paper with a polymer coating.

For 10 tablets in a contour non-cellular package of paper with a polymer coating.

For 10, 20, 30 or 50 tablets in cans of polymer.

Each bank or 1, 2, 3, 4, 5 contour packs together with the instruction for use are placed in a pack of cardboard for consumer containers.

Storage conditions:

In a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002676 / 01-2003

Date of registration:18.05.2010

Expiration Date:Unlimited

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp27.09.2017

Illustrated instructions

Instructions

Aspark (Asparcam)