Potassium and magnesium asparaginate - instructions for use, dose, side effects, contraindications

Indications:Hypokalemia, including the use of loop diuretics; as part of complex therapy for heart failure, coronary heart disease, heart rhythm disturbances (including myocardial infarction, cardiac glycoside intoxication).

ICD-10

IV.E70-E90.E87.6 Hypokalemia

IX.I30-I52.I50 Heart failure

IX.I20-I25 Cardiac ischemia

IX.I30-I52.I49 Other disorders of the heart rhythm

Contraindications:

Hypersensitivity, acute and chronic kidney failure, hyperkalemia, hypermagnesia, insufficiency of the adrenal cortex, AV blockade, oliguria, anuria, cardiogenic shock (arterial pressure less than 90 mm Hg), acute metabolic acidosis, dehydration, hemolysis, severe myasthenia gravis.

Carefully:

Hypophosphatemia, urolithiasis (associated with a violation of calcium, magnesium and ammonium phosphate metabolism), pregnancy, breast-feeding. For parenteral administration (in addition): severe hepatic insufficiency, metabolic acidosis, the risk of edema, chronic renal failure (in the event that the regular monitoring of magnesium concentration in the serum is impossible - the risk of cumulation).

Pregnancy and lactation:

Adequate and well-controlled studies in humans and animals have not been conducted. There is no information on the penetration into breast milk.

The category of FDA recommendations is not defined.

Dosing and Administration:

Inside after eating 2 tablets (pills) 3 times a day; preventive and maintenance dose - 1 dragee 3 times a day for 3-4 weeks.

Intravenously slow or drip. For intravenous jet slow injection for injection: 10-20 ml dilute in 5-10 ml of 0.9% sodium chloride solution or in the same volume of 5% dextrose solution - 1-2 times a day. Solution for infusions - 300 ml 1-2 times a day at a speed of 20-30 drops per minute. For infusions, you can apply the solution in ampoules, previously diluted at the rate of 10 ml of solution (1 ampoule) per 100 ml of 5% dextrose solution.

Side effects:

On the part of the digestive system: nausea, vomiting, diarrhea, dry mouth, or burning pain in the epigastric region (anatsidnyh patients with gastritis or cholecystitis), flatulence, ulceration of the gastrointestinal mucosa.

Other: Hyperkalemia (nausea, vomiting, diarrhea, and paresthesia) gipermagniemiya (facial flushing, thirst, lowering blood pressure, hyporeflexia, respiratory depression, convulsions), AV-block, paradoxical reaction (increase in the number of extrasystoles), dyspnea, pruritus; with intravenous injection - dizziness, phlebitis.

Overdose:

Hyperkalemia. Hypermagnesia.

Interaction:

While the use of β-blockers, cyclosporin, potassium-sparing diuretics, heparin, ACE inhibitors, nonsteroidal antiinflammatory drugs increases the risk of hyperkalemia.

With simultaneous application with general anesthetics, the inhibitory effect on the central nervous system increases.

While the use of atracurium, decamethonium, succinyl chloride and suxamethonium may increase neuromuscular blockade.

Enhancement of negative dromo- and batmotropic effects of antiarrhythmics.

Special instructions:

Common for potassium and magnesium salts.

Monitoring the concentration of potassium and magnesium in the serum, ECG, kidney function.

Distinguishing characteristics: during the cardiosurgical operations on the antiarrhythmic effect is equal to potassium chloride.

Correction of levels of either potassium or magnesium can lead to an undesirable increase in the concentration of the second ion, especially against the background of renal failure.

1 g magnesium aspartate (dibasic) corresponds to 3.1 mmol of magnesium.

1 tablet / tablet contains 36.2 mg of potassium ions and 11.8 mg of magnesium ions.

1 ml of solution for injection contains 45 mg of potassium asparaginate (10.3 mg of potassium ions) and 40 mg of magnesium asparaginate (3.4 mg of magnesium ions).

It is not represented in the United States Pharmacopeia.

Instructions

Potassium and magnesium asparaginate (Kalii asparaginas + Magnii asparaginas)