Biofestal (Biofestal)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHemicellulase + Bile components + PancreatinHemicellulase + Bile components + Pancreatin
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    • Dosage form: & nbsppills
    Composition:
    Active substances: pancreatin - 192-210 mg, hemicellulase - 50 mg, bovine bile extract - 25 mg;
    Excipients:
    the nucleus - sodium chloride, lactose, soluble starch, microcrystalline cellulose, talc, magnesium stearate, colloidal silicon dioxide;
    composition of the shell - cellulose acetate-phthalate, diethyl phthalate, hydroxypropylmethylcellulose, titanium dioxide, talc.
    Description:Round biconvex dragee of white or almost white color, a kind on a break: a kernel from light up to dark brown color, with a characteristic smell of a pancreatin.
    Pharmacotherapeutic group:Digestive enzyme agent
    ATX: & nbsp

    A.09.A.A   Enzyme preparations

    Pharmacodynamics:
    Compensates the insufficiency of the exocrine function of the pancreas, has a proteolytic, amylolytic and lipolytic effect.
    The enzymes included in the pancreatin (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides. Improves the functional state of the gastrointestinal tract, normalizes the digestive process.
    Pancreatic enzymes are released from the dosage form in the alkaline medium of the small intestine. protected from the action of gastric juice shell.
    Indications:Substitution therapy with exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, Remkheld syndrome (gastrocardial syndrome), cystic fibrosis; flatulence, diarrhea of ​​non-infectious genesis.
    Disturbance of the assimilation of food (state after resection of the stomach and small intestine); to improve the digestion of food in people with normal gastrointestinal function in the event of errors in nutrition (eating fatty foods, a large amount of food, irregular meals) and in cases of malfunctioning, sedentary lifestyle, prolonged immobilization.
    Preparation for X-ray and ultrasound examination of the abdominal organs.
    Contraindications:
    Hypersensitivity to the components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis, children under 6 years.
    Pregnancy and lactation:
    The safety of pancreatin in pregnancy is not well understood. The application is possible in cases where the expected benefit for the mother exceeds the potential risk to the fetus. During the lactation period, the use of pancreatin is not contraindicated.
    Dosing and Administration:
    Inside. The drug is taken during or after meals, without chewing and washing with non-alkaline liquid (water, fruit juices).
    The dose is determined individually depending on the degree of digestion disorders. Adults usually - 1 - 2 pills 3 times a day.
    In children older than 6 years, the drug is used as directed by a doctor. The dose is determined individually.
    The duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in the diet) to several months or years (if necessary, permanent replacement therapy).
    Side effects:
    Allergic reactions. Rarely - diarrhea, constipation, a feeling of discomfort in the stomach, nausea (the cause-and-effect relationship of the development of these reactions with the action of pancreatin is not established, tk.these phenomena refer to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, it is possible to develop hyperuricosuria, hyperuricemia. In cystic fibrosis, if the necessary dose of pancreatin is exceeded, the development of strictures (fibrous colonopathy) in the ileocecal region of the ascending colon may be possible.
    When using pancreatin in high doses, children may experience perianal irritation and irritation of the mucous membrane of the oral cavity.
    Overdose:
    Symptoms: hyperuricosuria, hyperuricemia. Children have constipation.
    Treatment: withdrawal of the drug, symptomatic therapy.
    Interaction:
    When using pancreatin, it is possible to reduce the absorption of iron and folic acid. The simultaneous use of antacid agents containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of pancreatin.
    Special instructions:
    Cystic fibrosis does not recommend the use of pancreatin in high doses due to an increased risk of stricture (fibrous colonopathy). The dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.
    Form release / dosage:
    Dragee.
    Packaging:For 10 dragees in a contour non-jawed package or 10 dragees in a contour squam. 1, 2, 3, 5, 10 contour mesh or cell-free packages together with the instruction for use are placed in a pack of cardboard.
    Storage conditions:
    At a temperature not higher than + 25 ° C, in a dry place, protected from light, out of reach of children.
    Shelf life:4 years.
    Terms of leave from pharmacies:Without recipe
    Registration number:LS-000282
    Date of registration:20.05.2005
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOFARMA, CJSC BIOFARMA, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp12.02.2017
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