Diazolin - instructions for use, doses, side effects, contraindications

H1-histamine receptor blocker. Has anti-allergic effect, reduces swelling of mucous membranes.Weakens the action of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of lowering blood pressure and increasing the permeability of blood vessels. Minorly penetrating the central nervous system, unlike antihistamines of the first generation, does not have a pronounced sedative and hypnotic effect. Has weakly expressed M-cholinergic and anesthetic properties.

The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days.

Pharmacokinetics:

Quickly absorbed from the gastrointestinal tract, penetrates into all tissues of the body. Bioavailability varies between 40-60%. The half-life of the plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier. Metabolised in the liver by methylation, induces microsomal enzymes of the liver, excreted by the kidneys.

Indications:

Prophylaxis and treatment of allergic rhinitis, hay fever, urticaria, Quincke edema, allergic dermatoses, accompanied by pruritus (eczema, neurodermatitis); allergic conjunctivitis, skin reaction after an insect bite.

Contraindications:

Hypersensitivity, prostatic hyperplasia, angle-closure glaucoma, gastric and duodenal ulcer, inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, heart rhythm disorders, pregnancy, lactation period, children under 3 years old, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

Carefully:

Hepatic and / or renal failure (dose adjustment and interval between doses may be required).

Pregnancy and lactation:

It is not recommended to take the drug during pregnancy. During breastfeeding should stop taking the drug.

Dosing and Administration:

Inside, not liquid, during or immediately after eating.

Adults and children from 12 years of age are prescribed 100 mg 1-3 times a day. Maximum doses for adults: single dose - 300 mg, daily - 600 mg.

The duration of the course of treatment is determined by the nature of the disease and the therapeutic effect achieved.

For children aged 3 to 5 years - 50 mg 1-2 times a day, 5 to 10 years - 50 mg 2-3 times a day, 10 to 12 years - 50 mg 2-4 times a day day.

Side effects:

From the gastrointestinal tract: has an irritating effect on the mucous membrane of the gastrointestinal tract, manifested dyspepsia (heartburn, nausea, pain in the epigastric region).

From the nervous system: dizziness, paresthesia, tremor, fatigue, drowsiness, anxiety (at night), slowing the speed of the psychomotor reaction.

Other: dry mouth, delayed urination, allergic reactions, extremely rarely - granulocytopenia and agranulocytosis.

Children - paradoxical reactions: increased excitability, irritability, tremor, sleep disturbances.

Overdose:

Symptoms: Confusion, drowsiness, impaired coordination of movements. In the future, as the intake of the drug is absorbed, symptoms of oppression of the central nervous system may increase until the onset of coma. Overdose can also lead to a stimulating effect on the central nervous system (more often observed in children). Also, manifestations of anticholinergic action may develop: dry mouth, pupil dilated, blood flow to the upper half of the trunk, abnormalities of the gastrointestinal tract (nausea, epigastric pain, vomiting).

Treatment: Removing the drug, washing the stomach, taking activated charcoal, if necessary - symptomatic therapy.

Interaction:

Strengthens the action of ethanol, sedatives.

Special instructions:

Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Tablets of 50 mg and 100 mg.

Packaging:

For 10 tablets in a planar cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

1, 2 or 3 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years 6 months.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000455

Date of registration:10.06.2010

The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Manufacturer: & nbsp

VALENTA PHARMACEUTICS, JSC Russia

Information update date: & nbsp10.06.2010

Illustrated instructions

Instructions

Diazoline (Diazolin)