Diazolin - instructions for use, doses, side effects, contraindications

Composition:each 50 mg tablet contains:
of the active substance: diazolin (mebhydroline napadisylate) 50 mg;
Excipients: lactose (sugar milk) - 34.50 mg, potato starch - 10.00 mg, povidone (polyvinylpyrrolidone) - 3.50 mg, sodium carboxymethyl starch - 1.00 mg, magnesium stearate - 1.00 mg.

each 100 mg tablet contains:
of the active substance: diazoline (mebhydroline napadisylate) 100 mg; Excipients: lactose (milk sugar) - 69.00 mg, potato starch - 20.00 mg, povidone (polyvinylpyrrolidone) - 7.00 mg, sodium carboxymethyl starch - 2.00 mg, magnesium stearate - 2.00 mg.

Description:tablets from white to white with a creamy or greenish hue of color, flat-cylindrical shape, with a facet on both sides and risk from one side.

Pharmacotherapeutic group:antiallergic agent - Hi-histamine, receptor blocker.

ATX: & nbsp

R.06.A.X.15 Mebrogroline

R.06.A.X Other antihistamines for systemic use

Pharmacodynamics:Diazoline is a blocker of H1-histamine receptors. Has anti-allergic effect, reduces swelling of mucous membranes. Weaken the spasmogenic effect of histamine against the smooth muscles of the bronchi, the intestines, and reduce the hypotensive effect of histamine, as well as its effect on vascular permeability. Unlike antihistamines, the first generation does not have significant sedative and hypnotic effects.
The therapeutic effect develops after 15-30 minutes, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days.

Pharmacokinetics:Quickly absorbed from the gastrointestinal tract. Bioavailability varies between 40-60%. The half-life of the plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier, is metabolized in the liver by methylation, induces enzymes of the liver, is excreted from the body by the kidneys.

Indications:Hay fever, allergic rhinitis, hay fever, hives, Quincke's edema, food and drug allergies, dermatoses,accompanied by skin itching (eczema, neurodermatitis, etc.), conjunctivitis, skin reaction after an insect bite.

Contraindications:Hypersensitivity, prostatic hyperplasia, angle-closure glaucoma, peptic ulcer and duodenal ulcer, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac arrhythmias (having vagolytic action, can improve AV conduction and promote the development of supraventricular arrhythmias).
Pregnancy, lactation.
Children under 3 years (for this dosage form).

Carefully:With caution: hepatic and / or renal failure (dose adjustment and interval between doses may be required).

Pregnancy and lactation:Contraindicated in pregnancy and lactation.

Dosing and Administration:Diazolin is administered orally after a meal.
Adults and children from 12 years to 0.05-0.1 g 1-2 times a day for children from 3 years to 0.05 g 1 - 2 times a day, from 5 years to 0.05 g 2 - 3 times in a day. Higher doses for adults: single - 0.3 g, daily - 0.6 g. The course of treatment is prescribed by a doctor and is determined by the nature of the disease and the therapeutic effect achieved.

Side effects:From the digestive system: irritating effect on the mucous membrane of the gastrointestinal tract, manifested by dyspeptic phenomena (heartburn, nausea, pain in the epigastric region, etc.).
From the nervous system: dizziness, paresthesia, tremor, fatigue, drowsiness, anxiety (at night), slowing the reaction rate. Other: dry mouth, urinary disorders, allergic reactions. It is extremely rare occurrence of granulocytopenia and agranulocytosis.
Children - paradoxical reactions: increased excitability, irritability, tremor, sleep disturbances.

Overdose:Symptoms: oppression or excitation (especially in children) of the central nervous system, depression, confusion. Dilation of the pupils, dry mouth, shortness of breath, red face, paresis of the gastrointestinal tract, in children - development of seizures and death.
Treatment: there is no specific antidote. Induction of vomiting, gastric lavage. Symptomatic therapy includes drugs that increase blood pressure, oxygen, introduction of plasma-substituting fluids intravenously.Careful monitoring of breathing and blood pressure. You can not use adrenaline and analeptics.

Interaction:Potentsiruet action of alcohol and drugs, depressing the central nervous system.

Special instructions:It is not effective for bronchial asthma and anaphylactic shock.

Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions (driving a car, etc.).

Form release / dosage:Tablets of 50 mg and 100 mg.
For 10, 50 tablets in a contour mesh package made of a film of polyvinylchloride foil of aluminum printed lacquered.
By 10, 20, 30, 40, 50 or 100 tablets into a polymer container for medicines.
One container or 1, 2, 3, 4, 5, 6, 8 or 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Packaging:

blister of colorless film (1) / Instructions for Medical Use / -Bless Cardboard Box (10)
blister of colorless film (2) / Instructions for Medical Use / -Bless Cardboard Cardboard
blister of film of light-protective color (1) / Instruction on medical application / -Bless cardboard box (10)
blister of film of light-protective color (2) / Instruction on medical application / -Bless cardboard box

Storage conditions:Store in a dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.

Shelf life:3 years.
Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-007721/08

Date of registration:26.09.2008

The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp26.09.2008

Illustrated instructions

Instructions

Diazoline (Diazolin)