Diazolin - instructions for use, doses, side effects, contraindications

Composition:Active substance:
Mebidroline 50 mg 100 mg
napadisylate

Excipients:
granulated sugar 33.0 mg 33.0 mg
including:
[sucrose, 30.591 mg 30.591 mg
starch treacle] 2.409 mg 2.409 mg
sucrose 148.52 mg 196.53 mg
starch treacle 17,20 mg 18,80 mg
Povidone K-17 1.030 mg 1.406 mg
beeswax 0.0178 mg 0.0238 mg
paraffin liquid 0.039 mg 0.047 mg
talc 0.1932 mg 0.1932 mg

Description:

The dragee is white or white with a yellowish hue of color, a spherical shape. On a cross-section of a dragee of white or white with slightly kremovatym or slightly greenish shade of color. The surface of the dragee should be smooth, smooth, uniform in color.

Pharmacotherapeutic group:Antiallergic agent - H1-histamine receptor blocker.

ATX: & nbsp

R.06.A.X.15 Mebrogroline

R.06.A.X Other antihistamines for systemic use

Pharmacodynamics:

H1-histamine receptor blocker. Has anti-allergic effect, reduces swelling of mucous membranes. Weakens the action of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of lowering blood pressure and increasing the permeability of blood vessels. Slightly penetrating the central nervous system, unlike antihistamines of the first generation, does not have a pronounced sedative and hypnotic effect. Has mildly expressed M-cholinergic and anesthetic properties. The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1 -2 hours. The duration of the effect can reach 2 days.

Pharmacokinetics:

Quickly absorbed from the gastrointestinal tract, can cause irritation of the mucous membrane of the stomach, penetrates into all tissues of the body. Bioavailability varies between 40-60%. The half-life from the plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier. Metabolised in the liver by methylation, induces microsomal enzymes of the liver, excreted by the kidneys.

Indications:

Prophylaxis and treatment of seasonal and allergic rhinitis, hay fever, urticaria, Quincke edema, allergic dermatoses accompanied by pruritus (eczema, neurodermatitis, etc.), allergic conjunctivitis, skin reaction after an insect bite.

Contraindications:

Hypersensitivity to the components of the drug, prostatic hyperplasia, zakratougolnaya form of glaucoma, peptic ulcer of the stomach and duodenum, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac arrhythmias (having a vagolytic effect, can improve atrioventricular conduction and contribute to the development of supraventricular arrhythmias), children under 3 years of age, sugar deficiency / isomaltase, fructose intolerance, glucose-galactose malabsorption.

Carefully:

Use with caution in patients with hepatic and renal insufficiency (dosage adjustment and interval between doses may be required).

Pregnancy and lactation:

It is not recommended to use the drug during pregnancy. During breastfeeding should stop taking the drug.

Dosing and Administration:

Dragee should be taken orally, without chewing, during or immediately after eating. Adults and children from 12 years of age are prescribed 100 mg 1-3 times a day. Higher doses for adults: single dose - 300 mg, daily - 600 mg. Children from 3 to 5 years - 50 mg 1-2 times a day, 5 to 10 years - 50 mg 2-3 times a day, 10 to 12 years - 50 mg 2-4 times a day. The duration of the course of treatment is determined by the nature of the disease and the therapeutic effect achieved.

Side effects:

From the gastrointestinal tract: has an irritant effect on the mucous membrane of the gastrointestinal tract, manifested dyspepsia (heartburn, nausea, pain in the epigastric region, etc.).

On the part of the nervous system: dizziness, paresthesia, tremor, fatigue, drowsiness, anxiety (at night), slowing the speed of the psychomotor reaction.

Other: dry mouth, urinary retention, allergic reactions, granulocytopenia and agranulocytosis.

Children - paradoxical reactions: increased excitability, irritability, tremor, sleep disturbance.

Overdose:

Symptoms: confusion, drowsiness, impaired coordination of movement,oppression of the central nervous system (up to coma) or stimulating effect on the central nervous system (more often in children); manifestations of anticholinergic action: dryness of the oral mucosa, dilated pupils, "tides" of blood to the upper half of the trunk, nausea, vomiting, epigastric pain.

Treatment: drug withdrawal, gastric lavage, activated charcoal, symptomatic therapy.

Interaction:

Strengthens the action of ethanol, sedatives.

Effect on the ability to drive transp. cf. and fur:

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Dragee 50 mg and 100 mg.

Packaging:For 10 dragees in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.
By 1, 2, 3, 4, 5 or 10 contour mesh packages together with the instruction for use will be prevented in a pack of cardboard.

Storage conditions:

In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life:

3 years 6 months

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-001131

Date of registration:30.01.2012

The owner of the registration certificate:AVVA RUS, OJSC AVVA RUS, OJSC Russia

Manufacturer: & nbsp

AVVA RUS, OJSC Russia

Information update date: & nbsp30.01.2012

Illustrated instructions

Instructions

Diazoline (Diazolin)